Corning® HepGo™ 3D Liver Kit | 3D Liver Model

Improve accuracy and better mimic in vivo behavior in human liver models

Leveraging our 3D cell culture technology as well as our expertise in liver biology and ADME/Tox, Corning has developed an all-in-one solution for the development of 3D liver models that better recapitulate in vivo behavior. The Corning HepGo assay-ready 3D liver spheroid kit delivers a more physiologically relevant model over traditional 2D models for reliable, accurate drug safety screening and drug efficacy testing.

The HepGo assay-ready 3D liver spheroid kit is a plug-and-play solution that includes 96 pre-plated primary human hepatocyte (PHH) spheroids in a 96-well spheroid microplate (one uniform spheroid per well) and companion media. The kit provides easy access to 3D PHH liver spheroids, which may improve accuracy and efficiency in various culture applications, including hepatotoxicity assays.

With its assay-ready platform, the HepGo kit allows both imaging-based and biochemical assays to be performed on the same plate—no transfer required. This streamlines the process, reduces time and cost, and reduces the potential for error, empowering you to focus on generating reliable, accurate, reproducible data.

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Learn More About the Corning HepGo Assay-ready 3D Liver Spheroid Kit

Benefits

Benefits

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Pre-plated PHH spheroids in Corning 96-well spheroid microplates together with ready-to-use kit companion media
Convenient to use
Reduction in manual steps which results in saving time and cost on assay development
Consistent and stable liver spheroid morphology, viability, and hepatic functions of PHH spheroids in long-term culture
Increased sensitivity in 3D hepatotoxicity assays

Pre-plated PHH spheroids in Corning 96-well spheroid microplates together with ready-to-use kit companion media
Convenient to use
Reduction in manual steps which results in saving time and cost on assay development
Consistent and stable liver spheroid morphology, viability, and hepatic functions of PHH spheroids in long-term culture
Increased sensitivity in 3D hepatotoxicity assays

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Uniform Formation

Uniform Formation

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1,000 cells per well were plated in a Corning 96-well spheroid microplate. Image was taken on day 6 after spheroid formation.

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Consistency

Consistent PHH Spheroid Size Across the 96-well Microplate

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Assay-ready PHH spheroids show consistent size across the whole plate on the 96-well Corning spheroid microplates. Data shown for spheroid size measurement from 14 plates. More than 60 spheroids were measured for each microplate with average %CV = 4.1 for the spheroid diameter measurement for all 14 microplates.

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Applications Using Human Liver Spheroids

3D human PHH liver spheroids are emerging as a more physiologically and pathologically relevant preclinical human liver models for drug safety assessment and liver disease modeling.

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Co-Culture of Human Liver Cells

Co-cultures of liver spheroids made from human liver cells may be a useful model to better understand the roles of different non-parenchymal cells and cell-cell interactions under physiological and pathological conditions.

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The Next Frontier in Disease Modeling: Human Liver Spheroids and Ready-Made Kits

With the low predictive value of animal disease modeling, 3D liver spheroids are gaining popularity. Ready-made kits make them more accessible than ever.