3D Cell Culture | 3D Cell Culture Models | Corning

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Create in vivo-like functionality with optimized 3D cell culture models

Two-dimensional cell culture studies have played a pivotal role in furthering our understanding of developmental biol­ogy, tissue morphogenesis, disease mechanisms, drug discovery, large-scale protein production, tissue engineering, and regenerative medicine. However, the inability of cells to achieve in vivo-like structural organization and connectivity in 2D cell culture assays can limit or diminish many critical properties, from cellular morphology, viability, proliferation, and differentia­tion, to gene and protein expression, among many others.

The use of 3D cell culture models has dramatically increased since its inception more than two decades ago. Evidence strongly sug­gests that 3D cell cultures establish physiological cell-cell and cell-ECM interactions, and, as a result, they can mimic the specificity of native tissue with greater physiological relevance than conventional 2D cultures. This is particularly evident in applications such as stem cell culture and differentiation, cancer biology, drug and toxicity screening, and tissue engineering.

Corning® Matrigel® matrix is one of the original 3D cell culture tools. Over the years, our customers have done extraordinary things with this matrix, which has inspired us to develop new surfaces and additional tools for manual and high throughput 3D cell culture, including our new spheroid microplates with Ultra-Low Attachment surface.

Technical Documents

Application Support for 3D Cell Culture

Featured resources

Corning® Matrigel® Matrix

Helping Make 3D Cell Culture Easier Than Ever

Corning Matrigel matrix is being used in cutting edge applications across 3D cell culture, including organoid assays. 

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Corning Spheroid® Microplates

Take the Guesswork Out of 3D Cultures

Corning Spheroid Microplates Take the Guesswork Out of 3D Cultures

Take the guesswork out of 3D cultures Corning spheroid microplates simplify and streamline the creation of 3D cultures. 

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3D Spheroids Simplified

With Corning spheroid microplates you can generate and analyze 3D spheroids in the same microplate. 

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High Throughput Screening for 3D Cell Culture

See how Corning’s spheroid microplates and the Acumen® Cellista scanning laser cytometer  enables rapid, high throughput, 3D cell culture screening. 

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Support

Scientific Support–Setting a New Industry Standard

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Enable 3D Spheroid Formation with Corning Ultra-Low Attachment Surface

Enable 3D Spheroid Formation

Corning Ultra-Low Attachment surface—a unique hydrogel surface designed to prevent cell attachment—inhibits specific and nonspecific immobilization, which forces cells into a suspended state, enabling 3D spheroid formation.

Corning Ultra-Low Attachment surface—a unique hydrogel surface designed to prevent cell attachment—inhibits specific and nonspecific immobilization, enabling 3D spheroid formation.

Corning 96- and 384-Well Spheroid Microplates

Corning 96- and 384-Well Spheroid Microplates

Think automating 3D cell culture is difficult? Not anymore. Find out how simple it can be to automate your assay using our HTS-compatible spheroid microplates.

Think automating 3D cell culture is difficult? Not anymore. Find out how simple it can be to automate your assay using our HTS-compatible spheroid microplates.

Transwell® Permeable Supports

Transwell® Permeable Supports

Create in-vivo -like cell culture environment using Transwell permeable supports to enhance cell growth for both anchorage-dependent and feeder-independent cell lines.

Create in-vivo -like cell culture environment using Transwell permeable supports to enhance cell growth for both anchorage-dependent and feeder-independent cell lines.