Robust Activity, High Quality, First Choice by Researchers
The Corning® Gentest™ Supersomes™ recombinant drug metabolizing enzymes product line includes more than 40 different human and animal cytochrome P450 isoforms, UDP-glucuronsyl transferases (UGTs), Flavin-Containing Monooxygenases (FMOs), monoamine oxidases (MAOs), human aldehyde oxidase (AOs), soluble N-Acetyltransferases (NATs), and carboxylesterases (CESs).
These metabolic enzyme products are manufactured using baculovirus-transfected insect cells and exhibit very high levels of catalytic activities. Side-by-side comparisons of the catalytic activity with pooled human liver microsomes (HLMs) are available for many enzymes.
New to the product offering is Corning Supersomes Ultra Aldehyde Oxidase, a recombinant human AO enzyme which utilizes a mammalian cell-based expression system. This recent addition is meant to address issues associated with other approaches that may present different protein post-translation modifications which may lead to different function as compared to mammalian cells. This product will enable early assessment of the liability of AO for drug metabolism and clearance.
Specific data is available by email: Scientificsupport@corning.com
By choosing these superior quality reagents, you will have the tools you need for screening drug interactions, studying slowly metabolized chemicals, or manufacturing large-scale production of metabolites for structural identification.
Interested in trying Corning Supersomes Ultra Human Aldehyde Oxidase (AO)? Complete our short request form to get started.