Recombinant Metabolic Enzymes | Recombinant Enzyme Products | Corning

We use cookies to ensure the best experience on our website.
View Cookie Policy
/worldwide/en/corning-cookie-policy.html
_self
Accept Cookie Policy
Change My Settings
ESSENTIAL COOKIES
Required for the site to function.
PREFERENCE AND ANALYTICS COOKIES
Augment your site experience.
SOCIAL AND MARKETING COOKIES
Lets Corning work with partners to enable social features and marketing messages.
ALWAYS ON
ON
OFF

This site is best viewed in a modern web browser. Please update your browser for the best experience possible.

Close[x]

Corning® Gentest™ Supersomes™

Recombinant Drug Metabolizing Enzymes

Robust Activity, High Quality, First Choice by Researchers

The Corning® Gentest™ Supersomes™ recombinant drug metabolizing enzymes product line includes more than 40 different human and animal cytochrome P450 isoforms, UDP-glucuronsyl transferases (UGTs), Flavin-Containing Monooxygenases (FMOs), monoamine oxidases (MAOs), human aldehyde oxidase (AOs), soluble N-Acetyltransferases (NATs), and carboxylesterases (CESs).

These metabolic enzyme products are manufactured using baculovirus-transfected insect cells and exhibit very high levels of catalytic activities. Side-by-side comparisons of the catalytic activity with pooled human liver microsomes (HLMs) are available for many enzymes.

New to the product offering is Corning Supersomes Ultra Aldehyde Oxidase, a recombinant human AO enzyme which utilizes a mammalian cell-based expression system. This recent addition is meant to address issues associated with other approaches that may present different protein post-translation modifications which may lead to different function as compared to mammalian cells. This product will enable early assessment of the liability of AO for drug metabolism and clearance.

Specific data is available by email: Scientificsupport@corning.com

By choosing these superior quality reagents, you will have the tools you need for screening drug interactions, studying slowly metabolized chemicals, or manufacturing large-scale production of metabolites for structural identification.

Interested in trying Corning Supersomes Ultra Human Aldehyde Oxidase (AO)? Complete our short request form to get started.

Recombinant Supersome Enzymes

How to Buy

Purchasing Options

What’s New

Featured Products, Resources, and Support

NEW Corning® Supersomes Ultra Human Aldehyde Oxidase

NEW Corning® Supersomes Ultra Human Aldehyde Oxidase

A stable and reliable in vitro tool for the study of AO-mediated metabolism

NEW Corning® Supersomes Ultra Human Aldehyde Oxidase

Corning Supersomes Ultra Human Aldehyde Oxidase is a recombinant human AO enzyme that utlizes a mammalian cell-based expression system to address the issues associated with current market products, like recombinant AO expressed in bacteria.

Learn More

FAQ for Cytochrome P450 Inhibition Assays

FAQ for Cytochrome P450 Inhibition Assays

Check out this technical note to learn how to set up enzyme inhibition assays using supersome enzymes, HLM and hepatocytes

Corning® Gentest™ Cytochrome P450 Inhibition FAQ

Understand why and how are these assays are performed. Learn the tips and best practices for setting up these experiments.

Learn More

Need to outsource your ADME/Tox studies?

Need to outsource your ADME/Tox studies?

Get expert assistance from Corning Gentest Contract Service Team.

Corning Gentest Contract Research Services

Need specialized research support? Our ADME Study Directors stand ready to become an extension of your team—or your virtual partner—to help strengthen your ability to meet your drug discovery and pre-clinical goals. Corning Study Directors are knowledgeable and stay up-to-date with rapidly changing technological and regulatory developments.

Learn More

Technical Resources

Technical Resources

Technical Resources

We provide a range of technical materials (e.g., application notes, bulletins, instruction manuals, and selection and use guides) that support our products and key applications.

Learn More

Related Products

You may also be interested in these products.