High Content Screening (HCS) Microplates | Corning

Accelerate discovery with microplates for high content screening

Uncover biologically relevant information from cells and compounds in your drug discovery research with the sophisticated automated fluorescence microscopy, image acquisition, and analysis of high content screening (HCS).

A major challenge for cell-based imaging assays is selecting the ideal combination of plate type, magnification, and image quality that will yield reproducible and robust results. The Corning portfolio provides the highest quality microplates with the broadest range of options to meet this need.

Cell culture and plating techniques, the use of automation, and plate selection can all help reduce variability and improve results. The use of specialized microplates is especially critical for achieving optimal results. Key plate features include optimized flatness, thickness, film type, well bottom elevation, and surface type as they directly affect the optical quality, cell adherence, and well imaging access.

Microplate Platform Options

Corning has a number of high content screening microplate platform options available as seen in the table below. To access all high content screening microplate specifications and selection guide, you can download our High Content Screening brochure.

High Content Screening Microplates

Enhance Process and Performance

Enhance Process and Performance

Specialized Microplates

High Performance Plates for Cell-based Assays

Corning has been setting the standard for excellence in life sciences labware for over 85 years. We continue to be an industry leader focused on enhancing your assay process and performance with our cell culture products, microplates, and reagents. All Corning microplates adhere to strict manufacturing standards, process controls, and compliance testing to support consistent, reproducible performance.

Corning offers a variety of specialized microplates with a number of clear bottom substrate options to meet all your microscopy and high content imaging needs.

They are organized into 3 groups:

  • For 2X - 10X: Polystyrene microplates for standard microscopy and low magnification imaging
  • For 10X - 32X: 384-well and half-area 96-well high content standard base microplates in glass and Cyclic Olefin Copolymer (COC) for increased chemical resistance and high resolution microscopy
  • For 40X and over: 384-well and half-area 96-well high content low bottom elevation microplates in COC for use with high content imagers utilizing high magnification objectives with low numerical aperture immersion lenses

All COC and glass 384-well microplates feature a round well geometry that reduces reagent loss due to “wicking” and prevents cells from “clumping” in the corners.


Solutions for Cell-based Assays

Improve results with microplates for high resolution cell imaging

Technical Resources

Application Support for High Content Screening

Application Support for High Content Screening

Visualize your cells like never before with Corning High Content Screening Microplates

Corning glass bottom and cyclic olefin copolymer (COC) film bottom high content screening microplates deliver high optical quality for cell-based assays. With an unprecedented flatness (whole plate and intra-well), these microplates are ideal for high resolution cellular imaging applications.

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