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With the effectiveness of 3D spheroids in many areas of research including anti-cancer drug screening and in vitro tumor studies, the need for better methods to produce replicate spheroids of uniform size in mass quantities has emerged. 

Corning’s Elplasia technology addresses this need by enabling researchers to generate a high density of spheroids in a scaffold-free model using microcavity technology. Corning Elplasia technology is compatible with many cell types and may be used across many applications including; drug screening, cancer/tumor biology, stem cell biology, cell therapy research and 3D tissue engineering. 

The new Corning Elplasia 12K open well plate is designed similarly to the Corning Elplasia 12K flask, but in a microplate format with a removable lid enabling the straightforward bulk generation of uniform spheroids in one culture condition. 

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The Corning Elplasia 12K flask contains 152 microcavities per cm² in a vessel footprint similar to that of a T-75 flask. Gravity, in conjunction with the Corning Ultra-Low Attachment (ULA) surface, and a rounded microcavity geometry enable formation of approximately 12,000 spheroids of similar shape and size.

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Corning Elplasia plates can be used to generate, culture, and analyze hundreds to thousands of spheroids all in a standard plate footprint and are available in multiple formats, two well geometry types, and two surface coatings.

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