Corning® Matrigel® Matrix and Collagen

The Original and Best Extracellular Matrix

Proven. Trusted. Reliable.

For more than three decades, Corning Matrigel matrix has been the gold standard for recreating the extracellular environment in vitro. Derived from Engelbreth-Holm-Swarm (EHS) mouse sarcoma, Matrigel matrix provides a physiologically relevant scaffold that supports cell attachment, differentiation and migration – enabling translationally relevant results across cancer, stem cell and organoid research. 

Recreate In Vivo Conditions with Confidence

Matrigel matrix contains a complex mixture of extracellular matrix proteins – laminin, collagen IV, entactin, and heparan sulfate proteoglycans – that closely resemble the natural basement membrane. It’s unique composition and proven consistency allow researchers to:

  • Grow organoids that mimic native tissue architecture
  • Culture pluripotent stem cells with defined growth factor control
  • Create tumor invasion and angiogenesis assays
  • Model disease pathways for drug discovery and toxicity studies

Matrigel matrix is available in multiple formulations offering the flexibility to fit your workflow 

Matrigel Matrix Protocols and Resources

The Quality You Count On

  • #1 Referenced ECM in cancer research, stem cell biology, organoid culture, and 3D cell cultures
  • 13,000+ Citations on PubMed
  • Over 35+ years as a lab essential
  • Robust functional and pathological testing including multiple LDEV testing checkpoints
  • Wide selection of Matrigel matrix types to meet different application needs
  • Extensive complementary product portfolio including liquid handlingmediasera, and 2D and 3D Corning cultureware

The Service and Expertise you Expect

Corning Matrigel Matrix Products and their Applications


If you have questions on the status of a current ECM order or need support placing a new order, please contact your local Corning sales representative or our customer service department.