Corning® Matrigel® Matrix for Organoids | Surfaces

We use cookies to ensure the best experience on our website.
View Cookie Policy
_self
Accept Cookie Policy
Change My Settings
ESSENTIAL COOKIES
Required for the site to function.
PREFERENCE AND ANALYTICS COOKIES
Augment your site experience.
SOCIAL AND MARKETING COOKIES
Lets Corning work with partners to enable social features and marketing messages.
ALWAYS ON
ON
OFF

Consistent. Convenient. Certain.

Organoids have become increasingly popular in disease modeling and drug discovery as they resemble the composition and functionality of organs. Extracellular matrix (ECM) is an important component of the cell niche that provides biochemical cues and structural support, such as porosity and stiffness which mediates signaling for cell migration, cell behavior and polarization in organoid structures1,2.

Corning Matrigel matrix is one of the original and most widely referenced 3D cell culture tools, and our customers have done extraordinary things with this matrix. Corning’s new Matrigel matrix for organoid culture is an optimized version of this trusted product, formulated to support organoid growth and differentiation.

Corning Matrigel matrix for organoid culture is a convenient, ready-to-use solution that provides the consistency and reliability needed for successful organoid culture by employing the following steps:

  • Each lot is measured for its elastic modulus, which is indicative of matrix stiffness
  • Each lot is qualified to form stable "3D dome" structures commonly used in organoid culture
  • Verified to support growth and differentiation of mouse and human organoid cultures including:

– Long-term expansion of mouse small intestinal organoids for more than 7 passages with typical organoid budding morphology and marker expression3
– Growth and differentiation of polarized 3D organoids from primary human airway epithelial cells expressing typical markers4

  • Demonstrated to successfully grow organoids from both healthy and diseased cell origins

As an optimized matrix, Corning Matrigel matrix for organoid culture reduces the need for time-consuming screening, while providing the reproducibility and consistency essential for organoid research.

Order Now

1.  Hartman CD, et al. Extracellular matrix type modulates cell migration on mechanical gradients. Experimental Cell Research, vol. 359, no. 2, pp. 361-366, 2017.
2.  Bryant DM, et al. A molecular switch for the orientation of epithelial cell polarization. Developmental Cell, vol. 31, no. 2, pp. 171-187, (2014).
3.  Application note: CLS-AN-542, Culture of Mouse Intestinal Organoids in Corning® Matrigel® Matrix for Organoid Culture, K. Slater and H. Nandivada
4. Application note: CLS-AN-534, High Throughput Gene Expression Analysis of 3D Airway Organoids, H. Sherman, N. Elliott, A. White and A. Rossi

Application Areas

Growth and differentiation of organoids

Growth and differentiation of organoids

Organoids support advancements in the study of organogenesis, disease modeling, and subsequently patient-specific therapies. Stem cells and/or organ progenitors from normal or diseased tissue are mixed with Corning® Matrigel® matrix to create mini-organs of the: kidney, thyroid, liver, brain, lung, intestine, prostate, breast, esophagus, gastric, ovarian, and pancreas.

Corning Matrigel matrix is the most published hydrogel for organoid research due to its close resemblance to an in vivo environment, providing necessary growth factors, proteins, and the required matrix architecture.

Applications

Matrigel Matrix for Organoids in Action

Culture of Mouse Intestinal Organoids

Culture of Mouse Intestinal Organoids

See how the optimized Matrigel matrix for organoids supported the culture of mouse intestinal organoids.

Learn More

3D Airway Organoids

3D Airway Organoids

Discover researcher’s high throughput gene expression analysis of 3D airway organoids.

Learn More

How to Buy

Purchasing Options

Related Products

You may also be interested in these related products.

Spheroid Microplates

Spheroid Microplates

Spheroid Microplates

Generate, culture, assay, and analyze your spheroids all in one microplate.

Generate, culture, assay, and analyze your spheroids all in one microplate.

Transwell Permeable Supports

Transwell Permeable Supports

Transwell Permeable Supports

Transwell permeable supports are backed by extensive citations, protocols, and scientific support—all to help create a cell culture that more closely mimics an in vivo environment.

Transwell permeable supports are backed by extensive citations, protocols, and scientific support—all to help create a cell culture that more closely mimics an in vivo environment.

Corning® Cell Recovery Solution

Corning® Cell Recovery Solution

Corning® Cell Recovery Solution

Corning® Cell Recovery Solution enables the recovery of cells cultured on Corning® Matrigel® Basement Membrane Matrix for subsequent biochemical analyses.

Corning® Cell Recovery Solution enables the recovery of cells cultured on Corning® Matrigel® Basement Membrane Matrix for subsequent biochemical analyses.