2025 Corning 3D Cell Culture Summit

Coming to a city near you.

Coming to a city near you.

Researchers are increasingly turning to 3D cell cultures for a more physiologically relevant view of drug candidates potential for success and a more predictive understanding of drug effects in the body. Join us at one of four 3D Summit events coming this Fall for a day filled with lively and educational discussions on the latest developments in 3D models, and hear from thought leaders and innovators from top academic and industry organizations.

Summit Objectives

  • Gather leading researchers to discuss their 3D applications as well as novel and advanced models with Corning products.
  • Introduce new users to best practices and novel techniques to get started in 3D cell culture.
  • Networking and discussions among industry leaders on 3D workflow optimization and new ideas.

Register now

Seating is limited. We will send you reminders and updates on speakers, agenda, and other fun stuff that we will be adding to our event. More to come!

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Agenda

San Diego Speakers

Maya Gosztyla

Brainstorm Therapeutics

 

Presentation: Transforming CNS Drug Discovery: An AI-powered Human Brain Organoid Platform for Precision Medicine

 

Abstract: BrainStorm Therapeutics is transforming neurotherapeutic discovery by harnessing patient-derived brain organoids to model complex neurological diseases with unprecedented accuracy. Traditional animal and cell models often fail to capture the intricacies of human brain biology, limiting therapeutic success. Our platform generates 3D brain organoids from patient iPSCs that faithfully recapitulate disease-relevant cell types, neural circuits, and phenotypes, including dopaminergic neuron loss and lipid metabolism defects seen in Parkinson’s disease. These models serve as a foundation for high-content screening, transcriptomic profiling, and functional analysis, enabling us to uncover both generalizable and mutation-specific disease mechanisms. By layering in AI tools trained on multimodal biological data, we enhance our ability to map dysregulated pathways and prioritize therapeutic targets. Our “clinical trial in a dish” approach supports more predictive and patient-relevant drug testing, reducing cost and risk in early-stage R&D. We are extending this organoid-based platform to additional brain disorders like Rett Syndrome and CDKL5 Deficiency Disorder, with the goal of delivering precision treatments rooted in human biology. Corning products: Spheroid microplates, various TC-treated or ULA plates, Corning® Matrigel® matrix.

Maedeh Mozneb

Cedars Sinai Medical Center

 

Presentation: Advancing Cardiovascular and Space Biosciences Using iPSC-derived Cardiac Spheroids and Organoids in 3D Culture Systems

 

Abstract: At the Sharma Lab (Cedars-Sinai), we leverage 3D spheroid and organoid models to investigate human cardiac development, drug-induced cardiotoxicity, and stem cell differentiation under terrestrial and microgravity conditions. Our in-house generated cardiac organoids and spheroids, comprising iPSC-derived cardiomyocytes, fibroblasts, and endothelial cells, serve as robust models for developmental studies and high-sensitivity cardiotoxicity screening. Using agents such as doxorubicin and its less toxic analog, Spedox, we have demonstrated the reproducibility and responsiveness of our models in U-bottom, low-adhesion plates and recently transitioned to Corning’s® Elplasia® plates for improved uniformity and scalability. In collaboration with vascular biology teams, we are also exploring the fusion of separately patterned cardiac and endothelial spheroids to model vascularization dynamics. Further, our lab integrates space biosciences by sending cardiac and neural spheroids into orbit to study iPSC differentiation, vascularization, and functional maturation in microgravity. These high-throughput spaceflight investigations rely on robust ground controls prepared in Corning 3D culture systems, which have proven essential for consistency and translational insight. This talk will highlight our methodologies, key findings, and the pivotal role of Corning’s 3D platforms in enabling both Earth-based and space-based tissue engineering research.

Houston Speakers