Neural organoids—also known as cerebral organoids—are generated from pluripotent stem cells (PSCs). Embryoid bodies derived from induced PSCs (iPSCs) are encapsulated in Corning® Matrigel® Matrix droplets and cultured in differentiation media toward a cerebral phenotype on an agitation-based platform. These “mini-brains” can help us understand development of the human brain and help evaluate inherited and acquired brain diseases.
Publications
Lancaster et al pioneered generation of neural organoids from human PSCs (hPSCs). Here we have developed a human pluripotent stem cell-derived three-dimensional organoid culture system, termed cerebral organoids, that develop various discrete, although interdependent, brain regions.
Cerebral organoids, three-dimensional cultures that model organogenesis, provide a new platform to investigate human brain development. High cost, variability and tissue heterogeneity limit their broad applications. Discover how researchers developed a miniaturized spinning bioreactor (SpinΩ) to generate forebrain-specific organoids from human iPSCs.
Recent advances in stem cell technologies that enable the generation of human brain organoids from PSCs may enhance our understanding of the development of the human brain.
Using a culture system as a model to study human intestinal development, researchers were able to develop human enteroendocrine cells in vitro.
See how researchers successfully cultured midbrain-like organoids (MLOs) bearing features of the human midbrain, which may provide a tractable in vitro system to study the human midbrain and its related diseases.
