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Webinar #1 Q&A >

Presenter: Dr. Guillaume Gauron

What is flow chemistry? What are the advantages of running processes in a continuous way? How does Corning technology apply to it? This webinar focuses on several cases of flow chemistry applications that have been seamlessly transferred from lab scale directly to industrial production.

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Webinar #2 Q&A >

Presenter: Dr. Philippe Roth

Processes can be “translated” from traditional batch recipes to flow, or developed from scratch in flow. This course aims to help you apply the knowledge you have acquired in batch chemistry to get insight into flow chemistry. We’ll see how to analyse batch processing data in order to successfully transition from batch to flow and how to avoid common mistakes.

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Webinar #3 Q&A >

Presenter: Mr. Marc Winter

What are the ideal conditions and hurdles to move to flow chemistry? The benefits of microreactors and flow chemistry have been demonstrated across the chemical manufacturing industry for a variety of processes, but not every process is a good candidate.

Watch this webinar to identify the potential benefits of switching to flow chemistry and gather general advice and hints that will help you decide if flow chemistry would be a good fit for your process.

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Webinar #4 Q&A >

Presenter: Dr. Philippe Roth

Due to its interaction with matter, ultraviolet (UV) light can trigger specific reactions and open new routes. Photochemistry is a powerful tool but is often underused by scientists. However, with the improvement of global photochemistry technologies and increased adoption of flow chemistry, new options have emerged. This course highlights the key parameters to look at while performing photochemistry using Advanced-Flow Reactor Technology.

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Webinar #5 Q&A >

Presenter: Dr. Ancuta Musina

Corning® Advanced-Flow™ Reactors have been designed to maximize mixing and heat transfer. Consistent and pulseless flow is a key parameter for flow chemistry as any fluctuation in the flow of the chemical can cause the final product to drift out of tolerance. Therefore the selection of appropriate dosing pumps is paramount for a successful continuous-flow process. In the same time, to benefit of the reactor's heat transfer efficiency, the choice of the heat exchange unit is very important. Watch this webinar to learn how to pair material dosing lines (e.g., pumps, flow meters) and temperature controllers (e.g., chillers, heat exchangers) with your continuous flow reactor.

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Presenter: Dr. Jean-Christophe Monbaliu

This webinar illustrates the rationale behind the development of continuous flow processes relying on molecular oxygen. The use of oxygen for large scale preparative applications is often seen as challenging in organic chemistry both for safety and practical issues. The direct use of molecular oxygen will be illustrated for the preparation of value-added intermediates for pharmaceutical production or other high-end applications. The generation and use of much more reactive oxygenated species, such as singlet oxygen, will be documented as well for preparative chemistry and for the oxidative destruction of chemical warfare agents. Such applications rely on the synergistic combination of light, an organic photosensitizer and ground state molecular oxygen. 

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Webinar #7 Q&A >

Presenter: Dr. Philippe Roth

Emerging as a mega-trend and shaping the world in a new way, nanoparticles are everywhere. The ability to synthesize them remains challenging and requires extreme precision. As flow chemistry is a powerful tool for synthesis, it can offer a different way of thinking and synthesizing nanoparticles. This talk shows through different examples the impact flow chemistry can have on the field.

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Presenter: Mr. Marc Winter

Corning AFR Technology has been designed to help the chemical and pharma industries optimize their processes and speed up their time to market. The great R&D work performed by Corning experts leads to a flow chemistry technology which is not only scalable but enables seamless scale-up.

This webinar presents some of the innovation developed and how this enables customers from around the world to move to production inherently safer and quicker while keeping high quality standards. Through examples and case studies we discuss how achieving production scale is possible as well as process design optimization.

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Presenter: Dr. Jason Williams

Photochemistry holds significant promise in organic synthesis, with the dissemination of a large number of new methodologies. As a result, there will be increasing pressure on process development chemists in coming years, to scale up photochemistry-containing routes developed on smaller scale. Continuous flow processing has a key role to play as an enabling technology, but comes with additional complexities. This webinar shows case studies from the CC FLOW labs, discussing the scale-up considerations for a range of photochemical processes.

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Presenter: Dr. Guillaume Gauron

Corning has a long track-record of innovation spanning our 170-year history, with materials science at our core. For more than 17 years, Corning has developed and evolved its AFR technology to help meet customer requirements. From the lab to multi-ton production scale, to reactors and auxiliaries; from academic collaboration to customer training and technical support, Corning AFR is committed to delivering high quality products and unparalleled support to our customers. This webinar gives more insight into our portfolio of equipment and related services.

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Presenters:
Dr. Andrea Adamo, Zaiput Flow Technologies
Trevor Murray, Zaiput Flow Technologies
Dr. Jean-Christophe Monbaliu, University of Liège
Dr. Guillaume Gauron, Corning Reactor Technologies

Flow chemistry provides a rather broad set of advantages that range from process robustness, ease of scale up, to access otherwise very challenging reaction conditions. Harvesting the full benefits of flow chemistry requires in-line work-up capabilities integrated within the flow process. In this talk, we highlight how in-line continuous and scalable liquid-liquid extraction provided by the Zaiput’s line of separators aids in a full continuous process integration which provides safe operation in a compact foot print. Specifically, the minimal internal volume, lack of head space and inherently safe continuous operation of the separators, provide a valuable tool to process hazardous materials. Further, the  scalability of the technology provides a straightforward path to the production of larger quantities of material. Among different examples, we will highlight a recently published case where flow reactions and workups are utilized to manage the reactivity and toxicity of α-chloronitroso derivatives in various conditions.

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Guest Presenter: Dr. Kejun Wu, Zhejiang University 

A lot of promising nanostructured materials (NM) technologies never reach the market due to issues with the scaling-up process required to produce large quantities. Microreactor-based processes offer considerable advantages, including excellent control of mixing, heat and mass transfer, reproducibility, and seamless transition from lab-scale to large production. This webinar showcases studies from Dr. Wu's group, discussing the hydrodynamics and mixing behaviour and Ag NM continuous production in Corning Advanced-Flow Reactors.

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Presenters: 
Dr. Dirk Hütten, Raybow PharmaScience
Alessandra Vizza, Corning Reactor Technologies

This webinar focuses on reaction design and scale-up for larger production. Attendees will explore the benefits of continuous flow reactions in pharmaceutical API & Intermediate manufacturing. Raybow Pharmaceutical has a long history in the field with experience in R&D as well as manufacturing with multiple continuous flow reactors, the largest one of which produces more than 140 tons API per year.

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Presenter:
Dr. Jean-Christophe M. Monbaliu, Associate Professor, University of Liège

This webinar illustrates our recent efforts for the upgrading of biobased polyols towards value-added chemicals. The combination of novel chemistry and unique process conditions opens up new possibilities in the area of green and sustainable development. In particular, we will discuss the preparation of organic carbonates, glycidyl ethers and derivatives, as well as cyclic phosphates from biobased polyols featuring Corning Advanced-Flow Reactor Technology.

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Presenter:
Dr. Xinjun (Eric) Wu, Manager, Corning Reactor Technology Center (China)

Corning AFR is committed to helping the next generation of scientists and chemists build a foundation in and fundamental understanding of flow chemistry and flow reactor operation. We introduced our Corning Nebula™ Education Kits to provide students a hands-on learning experience and exposure to a new technology that is inherently safer than batch reactors. This webinar gives more insight into our Corning Nebula education platform and Corning’s efforts and investment in developing talent for the pharmaceutical, fine chemical, specialty chemical, and new material industries.