ADME/Tox Reagents for Research | Xenobiotic Metabolism Research Tools | Corning

Under conventional 2D monolayer culture conditions, primary human hepatocytes (PHHs) rapidly lose their hepatic phenotypes and become unhealthy within several days.

ATP-binding cassette (ABC) transporters are an important piece of drug efflux and have a significant impact on drug pharmacokinetics, efficacy, and safety. BCRP and P-gp are two ABC transporters that current regulatory guidance has identified as important transporters to test for drug-drug interactions. 

With the introduction of the solute carrier (SLC) over-expressing Corning TransportoCells, we have expanded our TransportoCells offering to conduct screening and use a step-wise approach for drug-drug interaction assays.

See how our recently introduced TransportoCells products support in vitro assessment of drug interaction with SLC transporters. This new model provides a convenient “thaw and go” cell-based model with robust activity and consistent performance.

Gain access to exclusive select articles and research from SLAS Technology: Translating Life Sciences Innovation 2019 The Journal showcases ways in which researchers adapt advancements, including 3D cell culture, in technology for scientific exploration and experimentation.