Air Liquid Interface (ALI) Cell Culture | In Vivo Disease Modeling | Corning

Better represent in vivo biology in an in vitro environment with ALI

Better represent in vivo biology in an in vitro environment with ALI

Because it exposes one side of the culture to liquid media and surrounds the other with air, Air-liquid Interface (ALI) is ideal for studying respiratory tract epithelial cells, which interact with both liquid and air. ALI systems therefore allow researchers to more accurately mimic in vivo conditions compared to using conventional cell culture models. This makes them ideal to perform mechanistic studies of respiratory epithelial cells as drug permeation barriers; to model respiratory diseases like cystic fibrosis and asthma; to investigate essential dermal processes such as wound healing; and to advance understanding of respiratory epithelium infections including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). From asthma to COPD, ALI models have been critical in researching respiratory diseases. With the recent outbreak and severity of the COVID-19 virus, this technology is becoming even more critical in the race to understand and treat disease.

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Ask the Experts

Ask the Expert – Using Disease Models at the Air Liquid Interface to Advance Respiratory Disease Studies

With the popularity of these more complex models growing, we have assembled a team of experts to answer your questions on disease modeling using ALI tools and systems.

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Tissue Engineering

Tissue Engineering: The Latest 3D Cellular Models for Respiratory Drug Development

Learn how a company in Switzerland is harnessing the latest cell culture technology to build even more predictive 3D cellular models for respiratory disease research.

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Well Plates

Uses and Best Practices for ALI

Learn more about the tools, uses and techniques for air-liquid interface cultures.

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ALI Culture Research

ALI Culture Research

Air-liquid interface (ALI) cell cultures could play a growing role in the lab. Here’s what you need to know to get started.

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Scientific Support—Setting a New Industry Standard

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