Primary Hepatocytes | Human and Animal Hepatocytes | Corning

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Human and Animal Hepatocytes

Human and Animal Hepatocytes

Human and Animal Hepatocytes

One Proven Brand, from Metabolism Studies Through Pre-clinical Drug Development

Enhance the results of your research with Corning® Gentest™ Hepatic cell models. Corning provides both fresh and cryopreserved primary human hepatocytes to support major applications in drug and xenobiotic biotransformation. Cyropreserved hepatocytes from common pre-clinical animal species are also available. All primary hepatocyte products are pre-screened and extensively characterized, which provides researchers with the data necessary to select lots which are well-suited to their research needs.

To maximize post-thaw viability and recovery of Corning cyropreserved hepatocytes, a cryohepatocyte recovery kit was developed (Cat. No. 454534). The Kit is easy to use and requires only one centrifugation step prior to plating.

Also available now, are the noval Corning HepatoCells. This renewable hepatic cell model is the best alternative to primary human hepatocytes for ADME/Tox studies. 

Corning Gentest Human and Animal Hepatocytes

Cryopreserved hepatocytes
High quality primary human hepatocytes

High Quality Primary Human Hepatocytes

High Quality Primary Human Hepatocytes

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  • Pre-screened and characterized for transporter-mediated uptake and biliary efflux activity, metabolic activity, and CYP enzyme induction.
  • Support ADME assays such as drug metabolism, induction, transporter, and toxicity studies.
  • Maximized viability, recovery, and plating efficiency by using the Corning Gentest high viability recovery and plating medium or kit.
  • Support long-term, multi-site studies with large lot sizes.
  • Pre-screened and characterized for transporter-mediated uptake and biliary efflux activity, metabolic activity, and CYP enzyme induction.
  • Support ADME assays such as drug metabolism, induction, transporter, and toxicity studies.
  • Maximized viability, recovery, and plating efficiency by using the Corning Gentest high viability recovery and plating medium or kit.
  • Support long-term, multi-site studies with large lot sizes.

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Fresh Human Hepatocytes
Fresh Human Hepatocytes

Convenient and Robust Fresh Human Hepatocytes

Convenient and Robust

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  • Available as vialed suspension preparations and as plated monolayer cultures on Corning BioCoat™ Multiwell plates or flasks, including 6-, 12-, 24-, 48- and 96-well plates 
  • Robust performance and viability upon arrival using the exclusive Corning Falcon® Flip-Lock Packaging
  • No use of irritating film membranes, gel stabilizers, or preservatives that can interfere with your research
  • Available as vialed suspension preparations and as plated monolayer cultures on Corning BioCoat™ Multiwell plates or flasks, including 6-, 12-, 24-, 48- and 96-well plates 
  • Robust performance and viability upon arrival using the exclusive Corning Falcon® Flip-Lock Packaging
  • No use of irritating film membranes, gel stabilizers, or preservatives that can interfere with your research
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Primary Animal Hepatocytes
Primary Animal Hepatocytes

Primary Animal Hepatocytes

Primary Animal Hepatocytes

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  • Characterized for platability and many metabolic enzyme activities.
  • Suitable for metabolic stability studies, metabolite profiling, and cytotoxicity applications.
  • Maximized viability, recovery, and plating efficiency by using the Corning Gentest high viability recovery and plating medium or kit
  • Characterized for platability and many metabolic enzyme activities.
  • Suitable for metabolic stability studies, metabolite profiling, and cytotoxicity applications.
  • Maximized viability, recovery, and plating efficiency by using the Corning Gentest high viability recovery and plating medium or kit
Learn More
Non-Primary Cell Models
Corning HepatoCells – A Novel Renewable Hepatic Model to Primary Human Hepatocytes

Corning HepatoCells – A Novel Renewable Hepatic Model to Primary Human Hepatocytes

Corning HepatoCells

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  • Maintain key functional characteristics of primary hepatocytes 
  • Provide excellent lot-to-lot consistency
  • Unlimited supply
  • Suitable for CYP induction, toxicity studies and more (such as lipid metabolism, viral infection)
  • Maintain key functional characteristics of primary hepatocytes 
  • Provide excellent lot-to-lot consistency
  • Unlimited supply
  • Suitable for CYP induction, toxicity studies and more (such as lipid metabolism, viral infection)
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HepatoLink™

Get Alerts and Information When New Hepatocyte Isolation or Lots Are aAvailable.

Get Alerts When New Hepatocyte Isolation or Lots Are aAvailable.

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HepatoLink® is the Corning immediate response system providing researchers with instant notification when new hepatocyte isolation events occur. Upon registration, you will also receive donor characterization data from Corning. For your convenience, select a preferred contact method—e-mail, phone, and/or SMS text alerts.

HepatoLink® is the Corning immediate response system providing researchers with instant notification when new hepatocyte isolation events occur. Upon registration, you will also receive donor characterization data from Corning. For your convenience, select a preferred contact method—e-mail, phone, and/or SMS text alerts.

Register Now

How to Buy

Purchasing Options

Order Now

Order Now

It’s easy to purchase Corning Gentest hepatocytes online. Just browse our online catalog, and add products directly to your cart. Order direct with a credit card or use a purchase order if you have an account with Corning.

It’s easy to purchase Corning Gentest hepatocytes online. Just browse our online catalog, and add products directly to your cart. Order direct with a credit card or use a purchase order if you have an account with Corning.

Distributors

Distributors

For global customers outside of Canada, please contact your regional Corning office.

For global customers outside of Canada, please contact your regional Corning office.

Customer Service

Customer Service

If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.

If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.

Applications and Use

Hepatocytes in Action

What’s New

Featured Products, Resources, and Support

Assessing DDI Using Calibration Curve-based Approaches

Assessing DDI Using Calibration Curve-based Approaches

Use of calibration curve methodology and human hepatocytes to predict CYP induction potential.

Assessing DDI Using Calibration Curve-based Approaches with Human Hepatocytes

In a study conducted by Zhang et al., researchers were able to use Corning Gentest human cryohepatocytes to assess the amount of P450 induction in the liver by analyzing the concentration response curves of CYP3A4 mRNA in vitro, and established a predictive relationship between the change in AUC in humans and parameters from CYP3A4 mRNA activity in vivo.

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Need to Outsource Your Hepatocyte Studies?

Need to Outsource Your Hepatocyte Studies?

Utilize Corning Expertise to get the results you need. Find out what we offer.

Corning Gentest Contract Research Services

With more than 20 years’ experience in supporting drug discovery and development programs, our portfolio of in vitro studies can help address your DDI study needs and more. Corning Gentest Study Directors are knowledgeable and stay up-to-date with rapidly changing technological and regulatory developments.

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Chemicals Chemicals

Corning offers a wide range of chemicals to support metabolism-based assays utilizing Corning Gentest tissue fractions, including substrates, inhibitors, and metabolites.

Corning offers a wide range of chemicals to support metabolism-based assays utilizing Corning Gentest tissue fractions, including substrates, inhibitors, and metabolites.

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Connect with Corning

Connect with Corning

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