With over 20 years of experience, we have all the high quality reagents that meet your in vitro ADME study needs, from Gentest™ Supersome™ recombinant metabolic enzymes to primary hepatocytes.
Drug Metabolism
Drug Metabolism
A Proven Brand with a Wide Selection of Study Models
Brand with a Wide Selection of Study Models
Products
ADME Metabolism Product Offerings
Choose Your Model System
Learn More
Corning® Supersomes™ are recombinant enzyme products prepared from baculovirus-transfected insect cells with very high levels of catalytic activities. Corning also offers a range of P450 and non-P450 including: (UGTs), (FMOs), (MAOs), (NATs), (CESs).
New to the offering is Corning Supersomes Ultra Human Aldehyde Oxidase (AO), a stable and reliable in vitro tool for the study of AO-mediated metabolism, prepared from mammalian cell membranes.
The selection of high quality metabolic enzymes have higher catalytic activities than the native enzymes from human liver and other organs and comparable Km. These enzymes support essential assays such as reaction phenotyping, metabolic stability, and enzyme inhibition required for FDA new drug registration and other pharmacokinetic studies.
Corning® Supersomes™ are recombinant enzyme products prepared from baculovirus-transfected insect cells with very high levels of catalytic activities. Corning also offers a range of P450 and non-P450 including: (UGTs), (FMOs), (MAOs), (NATs), (CESs).
New to the offering is Corning Supersomes Ultra Human Aldehyde Oxidase (AO), a stable and reliable in vitro tool for the study of AO-mediated metabolism, prepared from mammalian cell membranes.
The selection of high quality metabolic enzymes have higher catalytic activities than the native enzymes from human liver and other organs and comparable Km. These enzymes support essential assays such as reaction phenotyping, metabolic stability, and enzyme inhibition required for FDA new drug registration and other pharmacokinetic studies.
Learn More
Key Features
- Native non-cell-based model
- Contain multiple enzymes in their native configuration
- Different fractions are enriched with different types of enzymes
- Easy to use
Applications
- Enzyme mapping
- Mechanistic study
- Drug clearance
- Metabolite ID
Key Features
- Native non-cell-based model
- Contain multiple enzymes in their native configuration
- Different fractions are enriched with different types of enzymes
- Easy to use
Applications
- Enzyme mapping
- Mechanistic study
- Drug clearance
- Metabolite ID
Learn More
Key Features
- Native cell-based model
- Contain multiple enzymes in their native configuration
- Technically more challenging to use than other models
Applications
- Enzyme induction
- Drug clearance
- Metabolite ID
- Hepatic toxicity
Key Features
- Native cell-based model
- Contain multiple enzymes in their native configuration
- Technically more challenging to use than other models
Applications
- Enzyme induction
- Drug clearance
- Metabolite ID
- Hepatic toxicity
Drug Metabolism Applications
Recombinant Human AO
Recombinant Human AO Expressed in HEK293
Review a recent study where a recombinant human AO enzyme using a mammalian cell based expression system enabled the early assessment of the liability of AO for drug metabolism and clearance.
Review a recent study where a recombinant human AO enzyme using a mammalian cell based expression system enabled the early assessment of the liability of AO for drug metabolism and clearance.
Learn More
Cytochrome P450 Enzyme Mapping
Cytochrome P450 Enzyme Mapping in Drug Discovery
Get an overview of approaches to assessing the contribution of individual CYP isoforms to a drug’s clearance at the stage of drug discovery.
Get an overview of approaches to assessing the contribution of individual CYP isoforms to a drug’s clearance at the stage of drug discovery.
Learn More
Effect of in vitro inducers
Effect of in vitro inducers on plated human hepatocytes
Review a trend analysis on the effect of fifteen CYP3A4 in vitro inducers on the induction of CYP2B6, CYP2C8, CYP2C9, CYP2C19 and CYP3A5 in plated human hepatocytes.
Review a trend analysis on the effect of fifteen CYP3A4 in vitro inducers on the induction of CYP2B6, CYP2C8, CYP2C9, CYP2C19 and CYP3A5 in plated human hepatocytes.
Learn More
Corning Gentest™ Hepatocytes FAQs
Corning Gentest™ Hepatocytes FAQs
Need more details on Corning Gentest Hepatocytes? Download our frequently asked questions to learn more.
Need more details on Corning Gentest Hepatocytes? Download our frequently asked questions to learn more.
Learn MoreHow to Buy
Purchasing Options
Order Now
It’s easy to purchase Corning Gentest metabolism products online. Just browse our online catalog, and add products directly to your cart. Order direct with a credit card or use a purchase order if you have an account with Corning.
It’s easy to purchase Corning Gentest metabolism products online. Just browse our online catalog, and add products directly to your cart. Order direct with a credit card or use a purchase order if you have an account with Corning.
Learn More
In the US, we sell direct to the customer. Only select distributors in Canada sell Corning metabolism products. For global customers outside of Canada, please contact your regional Corning office. Fresh human hepatocytes are not available globally.
In the US, we sell direct to the customer. Only select distributors in Canada sell Corning metabolism products. For global customers outside of Canada, please contact your regional Corning office. Fresh human hepatocytes are not available globally.
Easy Access to Customer Service and Support
Easy Access to Customer Service and Support
Learn MoreIf you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.
If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.
Get Assistance from Expert ADME Study Directors
Get Assistance from Expert ADME Study Directors
Learn MoreNeed expert assistance for your studies? We stand ready to become an extension of your team—or your virtual partner—to help strengthen your ability to meet your drug discovery and pre-clinical goals. The Corning Gentest Contract Research team is knowledgeable and up to date with rapidly changing technological and regulatory developments.
Need expert assistance for your studies? We stand ready to become an extension of your team—or your virtual partner—to help strengthen your ability to meet your drug discovery and pre-clinical goals. The Corning Gentest Contract Research team is knowledgeable and up to date with rapidly changing technological and regulatory developments.
