康宁产品如何帮助您模拟肿瘤微环境
传统上,Transwell通透性支持物可用于更好地了解细胞侵袭,因为细胞可以穿过细胞外基质 (ECM) 包被小室上的孔,更好地复制肿瘤细胞到达另一个组织的路径2。近年来,由于多细胞球可在低吸附培养板中轻松形成并嵌入ECM,因此利用多细胞球模型可以更好地了解肿瘤侵袭和血管生成机制3。借助共聚焦成像仪等成像技术,研究人员能够研究侵袭和血管生成的速度。
参考文献:
1. González-Orozco, Juan Carlos, et al. “In Vitro Models for Studying Tumor Progression.” Methods in molecular biology (Clifton, N.J.) vol. 2174 (2021): 193-206. doi:10.1007/978-1-0716-0759-6_12
2. Justus, Calvin R, et al. “Transwell In Vitro Cell Migration and Invasion Assays.” Methods in molecular biology (Clifton, N.J.) vol. 2644 (2023): 349-359. doi:10.1007/978-1-0716-3052-5_22
3. Chen, Yin-Quan, et al. "Early stage mechanical remodeling of collagen surrounding head and neck squamous cell carcinoma spheroids correlates strongly with their invasion capability." Acta biomaterialia 84 (2019): 280-292.