Corning Introduces New ADME/Tox Products Developed from Mammalian Cells for More In Vivo-like Testing

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Press release

Introducing New ADME/Tox Products Developed from Mammalian Cells for More In Vivo-like Testing

Corning Introduces New ADME/Tox Products

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Corning Introduces New ADME/Tox Products Developed from Mammalian Cells for More In Vivo-like Testing
Corning Introduces New ADME/Tox Products Developed from Mammalian Cells for More In Vivo-like Testing
CORNING, N.Y. | CORNING INCORPORATED | April 26, 2017

Corning Incorporated (NYSE: GLW) has expanded its ADME/Tox product offerings to include Corning® TransportoCells HEK293-derived ABC transporter membrane vesicles and Corning Supersomes Ultra Human Aldehyde Oxidase (AO) enzyme.

Building on its large line of Corning Gentest in vitro transporter models, TransportoCells provide an innovative cell model for solute carrier (SLC) transporter studies. Corning has now developed ATP-binding cassette (ABC) transporter membrane vesicles based on the TransportoCells technology platform using a mammalian cell expression system.

“Inside-out membrane vesicles have been considered a gold standard for studying drug-drug interactions with ABC transporters,” said Dr. Tony Frutos, business technology director for Corning Life Sciences. “But the membrane vesicles made from insect Sf9 cells infected with baculovirus have different membrane components from mammalian cells – as well as different protein post-translation modifications – and they sometimes lack consistency.”

Corning’s new ABC transporter vesicles are made from HEK cells transiently transfected to over-express a single human ABC transporter protein. Using this mammalian expression system, the new products avoid many disadvantages associated with insect cell expression systems. The product portfolio now includes four human ABC transporter vesicles and a control vesicle.

The company is also extending its line of Corning Gentest Supersome recombinant metabolic enzymes using a mammalian expression system. Corning Supersome Ultra Human AO is a stable and reliable in vitro tool for the study of AO-mediated metabolism, which has increasing importance in drug development.  As a robust and consistent screening platform, Corning Supersomes Ultra Human AO delivers significantly higher (3- to 4-fold higher) activity as compared to bacterial expression systems.

Corning Life Sciences brings new and innovative laboratory technologies to researchers worldwide and helps customers succeed by providing innovative, high quality products and services in the areas of polymer science, biochemistry and molecular biology, glass melting and forming, surface modification, and characterization science.

To learn more about Corning Life Sciences products, contact a customer service representative at (800) 492-1110; outside the United States, call (978) 442-2200; or visit www.corning.com/lifesciences. To learn more about Corning’s ADME/Tox products, please visit: https://www.corning.com/worldwide/en/products/life-sciences/products/adme-tox-research.html

Forward-Looking and Cautionary Statements

This press release contains “forward-looking statements” (within the meaning of the Private Securities Litigation Reform Act of 1995), which are based on current expectations and assumptions about Corning’s financial results and business operations, that involve substantial risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include: the effect of global political, economic and business conditions; conditions in the financial and credit markets; currency fluctuations; tax rates; product demand and industry capacity; competition; reliance on a concentrated customer base; manufacturing efficiencies; cost reductions; availability of critical components and materials; new product commercialization; pricing fluctuations and changes in the mix of sales between premium and non-premium products; new plant start-up or restructuring costs; possible disruption in commercial activities due to terrorist activity, armed conflict, political or financial instability, natural disasters, adverse weather conditions, or major health concerns; adequacy of insurance; equity company activities; acquisition and divestiture activities; the level of excess or obsolete inventory; the rate of technology change; the ability to enforce patents; product and components performance issues; retention of key personnel; stock price fluctuations; and adverse litigation or regulatory developments. These and other risk factors are detailed in Corning’s filings with the Securities and Exchange Commission. Forward-looking statements speak only as of the day that they are made, and Corning undertakes no obligation to update them in light of new information or future events.

Digital Media Disclosure

In accordance with guidance provided by the SEC regarding the use of company websites and social media channels to disclose material information, Corning Incorporated (“Corning”) wishes to notify investors, media, and other interested parties that it intends to use its website (http://www.corning.com/worldwide/en/about-us/news-events.html) to publish important information about the company, including information that may be deemed material to investors. The list of websites and social media channels that the company uses may be updated on Corning’s media and website from time to time. Corning encourages investors, media, and other interested parties to review the information Corning may publish through its website and social media channels as described above, in addition to the company’s SEC filings, press releases, conference calls, and webcasts.

About Corning Incorporated

Corning (www.corning.com) is one of the world’s leading innovators in materials science. For more than 160 years, Corning has applied its unparalleled expertise in specialty glass, ceramics, and optical physics to develop products that have created new industries and transformed people’s lives. Corning succeeds through sustained investment in R&D, a unique combination of material and process innovation, and close collaboration with customers to solve tough technology challenges. Corning’s businesses and markets are constantly evolving. Today, Corning’s products enable diverse industries such as consumer electronics, telecommunications, transportation, and life sciences. They include damage-resistant cover glass for smartphones and tablets; precision glass for advanced displays; optical fiber, wireless technologies and connectivity solutions for high-speed communications networks; trusted products that accelerate drug discovery and manufacturing; and emissions-control products for cars, trucks, and off-road vehicles.