ADME/Tox Reagents and Services

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Helping you make informed decisions in a continually changing environment.

Products and Services

Innovative, Valuable Reagents and Research

overview

A History of Advancing Drug Discovery Research

A History of Advancing Drug Discovery Research

For over 20 years, the Gentest brand has provided state-of-the-art reagents and expert ADME research services to empower your ADME/Tox research. Now, as part of Corning Life Sciences, the Gentest offering continues to grow, helping you stay on the leading edge of drug discovery and development.

Need one-on-one specialized research support? Our ADME Study Directors stand ready to become an extension of your teamor your virtual partnerto help strengthen your ability to meet your drug discovery and pre-clinical goals.
 

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Applications

Advancing Real-world Studies

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Corning® TransportoCells™ SLC transporter cells

Corning® TransportoCells™ SLC transporter cells

Corning TransportoCells are high performance, cryopreserved mammalian cells that overexpress a

Corning TransportoCells deliver robust data, while eliminating the time required to culture and maintain stable cell lines. Assays include:
• Reaction phenotyping to determine if a specific SLC transporter is capable of transporting a test compound from the outside to the inside of a cell.
• Kinetic assays to determine the Km and Vmax values for the uptake of a test compound.
• Inhibition profiling to determining IC50 and Ki values for...

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Corning Recombinant Enzyme Products

Corning Recombinant Enzyme Products

Corning Recombinant Enzyme Products or Supersomes™ Enzymes—are prepared from baculovirus

Supersomes™ Enzymes are ideal for screening high throughput drug interactions, studying slowly metabolized chemicals, or manufacturing large-scale production of metabolites for structural identification.

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Evaluation of Calibration Curve-based Approaches

Evaluation of Calibration Curve-based Approaches

Researchers use Corning® Gentest™ Human CryoHepatocytes to evaluate calibration curve-based

In a study conducted by Zhang et al, researchers were able to use Corning Gentest Human CryoHepatocytes to assess the amount of P450 induction in the liver by analyzing the concentration response curves of CYP3A4 mRNA in vitro, and established a predictive relationship between the chance in AUC in humans and parameters from CYP3A4 mRNA activity in vivo.

This research supports the use of calibration curve models and human hepatocytes to predict CYP3A4 induction potential in human patients, which can pave the way for clinical trials of potential new drug...

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Featured Resources

TransportoCells Services FAQs

With the introduction of the solute carrier (SLC) over-expressing Corning TransportoCells, we have expanded our TransportoCells services to conduct screening and use a step-wise approach for drug-drug interaction assays.

Questions? Download this FAQ on our new line of cryopreserved SLC transporter cells, or contact us.

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Webinar: A Novel “Thaw and Go” Cell-based Model to Study SLC Transporters

A Novel “Thaw and Go” Cell-based Transporter Model

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Keep Your Research Fresh

Register for HepatoLink™ to receive up-to-date notifications when fresh human hepatocytes are available.

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