Corning® Matrigel® Matrix for Organoids | Disease Modeling and Drug Discovery | Corning

Consistent. Convenient. Certain. Disease Modeling and Drug Discovery.

Organoids have become increasingly popular in disease modeling (including in COVID-19 disease modeling) and drug discovery as they resemble the composition and functionality of organs. Extracellular matrix (ECM) is an important component in generating 3D models, in order to provide biochemical cues and structural support, such as porosity and stiffness which mediates signaling for cell migration1, cell behavior and polarization2 in organoid structures.

Corning Matrigel matrix is one of the original and most widely referenced 3D cell culture tools, and our customers have done extraordinary things with this matrix. Corning’s new Matrigel matrix for organoid culture is an optimized version of this trusted product, formulated to support organoid growth and differentiation.

Corning Matrigel matrix for organoid culture is a convenient, ready-to-use solution that provides the consistency and reliability needed for successful organoid culture by employing the following steps:

  • Verified to support growth and differentiation of mouse and human organoid cultures including:

– Long-term expansion of mouse small intestinal organoids for more than 7 passages with typical organoid budding morphology and marker expression3
– Growth and differentiation of polarized 3D organoids from primary human airway epithelial cells expressing typical markers4

  • Each lot is measured for its elastic modulus, which is indicative of matrix stiffness
  • Each lot is qualified to form stable "3D dome" structures commonly used in organoid culture
  • Demonstrated to successfully grow organoids from both healthy and diseased cell origins

As an optimized matrix, Corning Matrigel matrix for organoid culture reduces the need for time-consuming screening, while providing the reproducibility and consistency essential for organoid research.

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1.  Hartman CD, et al. Extracellular matrix type modulates cell migration on mechanical gradients. Experimental Cell Research, vol. 359, no. 2, pp. 361-366, 2017.
2.  Bryant DM, et al. A molecular switch for the orientation of epithelial cell polarization. Developmental Cell, vol. 31, no. 2, pp. 171-187, (2014).
3.  Application note: CLS-AN-542, Culture of Mouse Intestinal Organoids in Corning® Matrigel® Matrix for Organoid Culture, K. Slater and H. Nandivada
4. Application note: CLS-AN-534, High Throughput Gene Expression Analysis of 3D Airway Organoids, H. Sherman, N. Elliott, A. White and A. Rossi

e-Books Available for Download

Organoids

3D Model Systems: Spheroids, Organoids and Tissue Models

Spheroids, organoids & more complex 3D systems have been invaluable to research. Download this guide demystifying 3D models with helpful tips & techniques to set your 3D culture up for success.

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Organoid

e-Book Download: Expert Guide to Advanced 3D Cell Culture

Download this e-book to learn more about 3D techniques used in basic research, as well as translational and clinical applications.

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All about Organoids eBook

Download e-Book: All about Organoids

Download the "All about Organoids" e-book to learn more about how to efficiently generate organoids, whether its for basic biology, disease modeling, drug discovery, personalized medicine, or regenerative medicine.

Download

Ultimate Guide to Matrigel

Ultimate Guide to Matrigel

Access facts, tips, and expert advice on the most widely used ECM in scientific research.

Download

Application Areas

Growth and differentiation of organoids

Growth and differentiation of organoids

Organoids support advancements in the study of organogenesis, disease modeling, and subsequently patient-specific therapies. Stem cells and/or organ progenitors from normal or diseased tissue are mixed with Corning® Matrigel® matrix to create mini-organs of the: kidney, thyroid, liver, brain, lung, intestine, prostate, breast, esophagus, gastric, ovarian, and pancreas.

Corning Matrigel matrix is the most published hydrogel for organoid research due to its close resemblance to an in vivo environment, providing necessary growth factors, proteins, and the required matrix architecture.

Applications

Matrigel Matrix for Organoids in Action

Solutions Applied

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