Ensure temperature consistency and minimize contamination risk with Corning® sample cooling and heating systems

Products

Corning CoolRack® and CoolSink® Thermo-conductive Modules

CoolRack and CoolSink Thermo-conductive Modules

Eliminate variability originating from tubes, plates, or wells placed directly into ice, dry ice, alcohol baths, water baths, and other cooling or heating temperature sources with Corning thermo-conductive modules.

CoolRack tube and CoolSink plate modules provide consistent temperature to all samples, stability, and organization—making sample cooling or heating error-free and reproducible.

Simply place your preferred module directly onto a temperature source between -196°C to >100°C and it will rapidly adapt to that temperature, ensuring +/- 0.1°C temperature uniformity across all samples. All CoolRack and CoolSink modules may be autoclaved, high heat sterilized or decontaminated with bleach, alcohol, or other disinfectants or lab detergents. All modules are compatible with all temperature sources.

Suggested applications include: cooling reagents such as restriction enzymes, dNTPs and antibodies, alcohol-free dry ice snap-freezing of tissue, virus and bacteria samples, and bench top cryogenic tube sorting in liquid nitrogen.

CoolRack and CoolSink thermo-conductive modules eliminate inconsistencies which occur due to inserting tubes or plates directly into ice, dry ice, water or alcohol baths, and other temperature sources. Simply place the CoolRack or CoolSink into the temperature source, and it will rapidly adapt to that temperature, ensuring uniformity when cooling, freezing, or heating/thawing.

Products

Extensive literature

Inconsistent sample temperature can result in misleading analytical results, which may jeopardize your research.

Corning’s family of sample cooling and heating systems enable consistent, reproducible temperature control across all tubes, plates, or wells when placed into cooling or heating sources such as ice, dry ice, liquid nitrogen, water baths, hot plates, or incubators. These solutions address the pitfalls of temperature regulation and reduce contamination risk, keeping your samples cool and stable while you work.

The platform is flexible, allowing you to choose the right components for your application and working style. No matter your desired configuration, you can always feel confident that you will keep your sample temperature stable and set your research up for success — right from the start.

CoolRack and CoolSink Versatility and Performance

Performance Test: A temperature probe was placed into a 2.0 mL cryogenic vial containing 1.0 mL of water. The tube was inserted into a CoolRack CF45 thermo-conductive module. The module was placed onto a ThermalTray platform in a 37°C water bath and allowed to equilibrate. The CoolRack CF45 module was then removed and placed onto dry ice and equilibrated to -78°C (0 - 15 minutes) and then returned to the water bath to re-equilibrate to 37°C (15 - 30 minutes). This experiment was repeated five consecutive times and temperature profiles were recorded.

 

Conclusion: The CoolRack CF45 module showed identical cooling profiles and phase transition (orange circles) over five consecutive freeze-thaw cycles.

Performance Test: A temperature probe was placed into a 2.0 mL cryogenic vial containing 1.0 mL of water. The tube was inserted into a CoolRack CF45 thermo-conductive module. The module was placed onto a ThermalTray platform in a 37°C water bath and allowed to equilibrate. The CoolRack CF45 module was then removed and placed onto dry ice and equilibrated to -78°C (0 - 15 minutes) and then returned to the water bath to re-equilibrate to 37°C (15 - 30 minutes). This experiment was repeated five consecutive times and temperature profiles were recorded.

 

Conclusion: The CoolRack CF45 module showed identical cooling profiles and phase transition (orange circles) over five consecutive freeze-thaw cycles.

On Ice

  • Adapts from ambient (25˚C) to <4˚C in 60-90 seconds*
  • Samples and labels stay dry, organized
  • Hours of ice cooling without direct ice contact
  • Reproducible method

 

*Average cooling rate from room temperature.

  • Adapts from ambient (25˚C) to <4˚C in 60-90 seconds*
  • Samples and labels stay dry, organized
  • Hours of ice cooling without direct ice contact
  • Reproducible method

 

*Average cooling rate from room temperature.

On Dry Ice

  • Adapts from ambient (25˚C) to -78˚C in approximately 5-7 minutes*
  • Eliminates ethanol from snap freezing
  • Samples are upright and organized as they freeze
  • Equal or better freezing rate as compared to direct immersion into dry ice or alcohol slurry
  • Reproducible method

 

*Average cooling rate from room temperature.

  • Adapts from ambient (25˚C) to -78˚C in approximately 5-7 minutes*
  • Eliminates ethanol from snap freezing
  • Samples are upright and organized as they freeze
  • Equal or better freezing rate as compared to direct immersion into dry ice or alcohol slurry
  • Reproducible method

 

*Average cooling rate from room temperature.

In Liquid Nitrogen

  • Adapts from ambient (25˚C) to approximately -150˚C in approximately 12-14 minutes*
  • Vapor barrier protects from ambient air
  • Samples are upright and organized as they freeze
  • No direct contact between samples and LN2
  • Reproducible method

 

*Average cooling rate from room temperature.

  • Adapts from ambient (25˚C) to approximately -150˚C in approximately 12-14 minutes*
  • Vapor barrier protects from ambient air
  • Samples are upright and organized as they freeze
  • No direct contact between samples and LN2
  • Reproducible method

 

*Average cooling rate from room temperature.

With Heat Sources

Use with water baths, hot plates, incubators and other heat sources to keep samples warm

Use with water baths, hot plates, incubators and other heat sources to keep samples warm

Ensure Uniformity

Problem

  • Non-uniform ice contact results in variable sample temperature
  • Disorganized, wet samples and labels
  • Shifting, sinking tubes and plates leads to contamination risk
  • Non-reproducible method
  • Non-uniform ice contact results in variable sample temperature
  • Disorganized, wet samples and labels
  • Shifting, sinking tubes and plates leads to contamination risk
  • Non-reproducible method
Solution

  • All samples <4˚C and uniform in temperature (+/- 0.1˚C) 
  • Samples are organized, secure and dry 
  • All tubes and plates are upright and indexed 
  • Reproducible method
  • All samples <4˚C and uniform in temperature (+/- 0.1˚C) 
  • Samples are organized, secure and dry 
  • All tubes and plates are upright and indexed 
  • Reproducible method

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