Matrigel Matrix

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Overview

Corning Matrigel Matrix

Cells behave better on Corning Matrigel matrix—the original, trusted extracellular matrix (ECM).

Nearly 30 years ago, researchers were looking for a way to grow mouse sarcoma cells. The solution? The development of Corning Matrigel matrix, a solubilized basement membrane preparation extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma, a tumor rich in such ECM proteins as laminin (a major component), collagen IV, heparin sulfate proteoglycans, entactin/nidogen, and a number of growth factors.

Today, this natural ECM-based hydrogel is among the most widely used models for 2D and 3D cell culture in vitro, enabling you to:

  • Improve the attachment and differentiation of both normal and transformed anchorage-dependent epitheliod cells, as well as other cell types.
  • Better mimic in vivo environments for 2D and 3D cell culture applications.

Applications

Corning Matrigel matrix is effective for the attachment and differentiation of both normal and transformed anchorage-dependent epithelioid and other cell types. These include neurons, Sertoli cells, chick lens, vascular endothelial cells, and hepatocytes.

Applications include:

  • Influencing gene expression in adult rat hepatocytes
  • 3D culture in mouse and human mammary epithelial cells
  • In vivo peripheral nerve regeneration
  • Metabolism and toxicology studies
  • The development of several types of tumor cell invasion assays
  • The in vitro and in vivo study of angiogenesis
  • In vivo propagation of human tumors in immunosuppressed mice
  • The maintenance of human embryonic stem cells and induced pluripotent stem (hiPS) cells
  • Neuronal differentiation of hiPS cells

Matrigel Matrix Quality Control Specifications

  • Mouse colonies routinely screened for pathogens via mouse antibody production (MAP) testing
  • LDEV-free EHS tumor
  • Extensive PCR testing performed on a number of pathogens, including LDEV, ensuring strict control of raw materials used during manufacturing
  • Tested and found negative for the presence of bacteria, fungi, and mycoplasma
  • Protein concentrations determined by Lowry method
  • Endotoxin units measured by Limulus Amoebocyte Lysate assay
  • Gel stability tested for a period of 14 days at 37°C
  • Biological activity determined for each lot using a neurite outgrowth assay; chick dorsal root ganglia, plated on a 1.0 mm layer of Corning Matrigel matrix, required to generate positive neurite outgrowth response after 48 hours without addition of nerve growth factor

How to Buy

Purchasing Options

Order Online

Order Online

It’s easy to purchase Matrigel matrix online. Just browse our online catalog, and add products directly to your cart. Order direct with a credit card or use a purchase order if you have an account with Corning.

It’s easy to purchase Matrigel matrix online. Order direct with a credit card or use a purchase order if you have an account with Corning.

Distributors

Distributors

Contact your authorized distributor to order Matrigel matrix.

Contact your authorized distributor to order Matrigel matrix.

Customer Service

Customer Service

If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.

If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.

Applications and Use

Matrigel Matrix in Action

What’s New

Featured Products, Resources, and More

Corning Matrigel Matrix FAQs

Corning Matrigel Matrix FAQs

Get answers to commonly asked questions about Corning Matrigel matrix.

Corning Matrigel Matrix Frequently Asked Questions

From growth factor concentration to cell recovery and storage, learn how to optimize your cell culture with Corning Matrigel matrix.

Learn More

Corning Matrigel Lot Selection and Reserve Tool

Corning Matrigel Lot Selection and Reserve Tool

Make sure your experiments are as consistent as possible. Reserve a consistent supply of Matrigel.

Extracellular matrices are complex biological reagents, and, like all biologically derived reagents, they may be subject to lot-to-lot variation. Our stringent quality control and manufacturing practices minimize variation. In addition, you can use the online Corning Matrigel Lot Selection and Reserve Tool to:

  • Set up a lot reserve, which simplifies storage and supply chain resources.
  • Find a production lot with similar specifications to the previously requested lot number.
Learn More

We can’t give you one reason to trust Matrigel....

We can’t give you one reason to trust Matrigel....

…Actually, we can give you five.

Five Reasons You Can Trust and Rely on Matrigel Matrix

From proven performance over the past 30 years to advanced in vivo applications, Matrigel matrix can support optimal cell growth in your lab. Consult this easy-to-reference infographic to see how Matrigel matrix can be an invaluable research tool for diverse applications. 

Learn More

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