Roller bottles, stacked vessels, microcarriers, bioreactors — researchers are flush with choices when selecting adherent platforms for vaccine production. Making the right choice requires scientists to consider a range of factors, from surface area to scale.
How you approach your choice can make or break a project's success — so think through your goals and test out your options. Thorough due diligence at the start will lead you to make the most effective choices and put you on track to achieve outcomes that match your expectations.
"Process optimization can look different for different research objectives, which means required materials and modalities can, too," said Chris Suarez, Ph.D., a field application scientist manager at Corning Life Sciences. "I always advise people to start with the end in mind. What are your objectives for your cell lines, and how do you envision your terminal seed train? These initial considerations can help drive platform selection."
As far as which factors to consider and why they make a difference, Suarez has suggestions.