Corning High Yield PERformance (HYPER) Technology | Vaccine, Protein, and Virus Production Products | Corning

Overview

Scale-up with Corning HYPER technology.

Scale-up with Corning HYPER technology.

The next generation High Yield PERformance (HYPER) technology lets you grow large quantities of adherent cells in a compact space. The cell production technology uses a unique ultra-thin gas-permeable film to eliminate the air gap within the vessel. This results in a substantial increase in cell growth surface area compared to traditional vessels of comparable cubic footprint.

Vessels with Corning’s HYPER technology are available for research applications (Corning HYPERFlask®) and biopharmaceutical production (Corning HYPERStack®). The benefits include:

  • Higher total cell yields than vessels with similar spatial footprints
  • Similar cell morphology, phenotype, and growth compared to traditional vessels
  • Closed system design ideal for large scale cells, protein therapeutics, vaccine, and virus production including those targeting Coronavirus and COVID-19 (HYPERStack).
HYPERStack Ebook Preview

Ebook: Improving Scale-up Efficiency with Corning® HYPER Technology

A compilation of research experiences in stem cell, viral vector and vaccine production.

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Do more with Corning HYPERStack Cell Culture Vessels

See how this closed system offers more surface area within a compact footprint.

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HYPER Platform Products

HYPERStack Cell Culture Vessel
HYPERStack Cell Culture Vessel

HYPERStack Cell Culture Vessel

HYPERStack Cell Culture Vessel

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Utilizing Corning HYPER technology - the ultra-thin gas-permeable film - allows the Corning HYPERStack cell culture vessel to be the most efficient, scalable cell culture vessel for adherent cell culture available today.

  • More cells – provides up to 5X the growth surface area of a traditional cell culture vessel of comparable footprint
  • Closed system – no open fluid manipulations
  • Scalable product – multiple size offerings support scale-up and scale-out
  • Ergonomic design – easier manipulation with handling accessories and equipment
  • Fixed media volume – 0.2 mL/cm2 fills vessel for less volumetric waste

Utilizing Corning HYPER technology - the ultra-thin gas-permeable film - allows the Corning HYPERStack cell culture vessel to be the most efficient, scalable cell culture vessel for adherent cell culture available today.

  • More cells – provides up to 5X the growth surface area of a traditional cell culture vessel of comparable footprint
  • Closed system – no open fluid manipulations
  • Scalable product – multiple size offerings support scale-up and scale-out
  • Ergonomic design – easier manipulation with handling accessories and equipment
  • Fixed media volume – 0.2 mL/cm2 fills vessel for less volumetric waste
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HYPERFlask Cell Culture Vessel
HYPERFlask Cell Culture Vessel

HYPERFlask Cell Culture Vessel

HYPERFlask Cell Culture Vessel

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The Corning HYPERFlask cell culture vessel offers 1720 cm² growth area in the footprint of a traditional 175 cm² flask by using a multilayered, gas-permeable growing surface for efficient gas exchange.

  • Innovative Design – 10 interconnected polystyrene growth surfaces
  • Optimal Growth – Corning CellBIND® Surface treated gas-permeable polystyrene for superior cell attachment and growth
  • Increase Cell Yield – 10-fold higher cell yields increases productivity and capacity and reduces processing time and incubator space
  • Automation Compatible – Bar coded and compatible with The Automation Partnership SelecT™ and CompacT™ SelecT™ cell culture systems with an upgrade

The Corning HYPERFlask cell culture vessel offers 1720 cm² growth area in the footprint of a traditional 175 cm² flask by using a multilayered, gas-permeable growing surface for efficient gas exchange.

  • Innovative Design – 10 interconnected polystyrene growth surfaces
  • Optimal Growth – Corning CellBIND® Surface treated gas-permeable polystyrene for superior cell attachment and growth
  • Increase Cell Yield – 10-fold higher cell yields increases productivity and capacity and reduces processing time and incubator space
  • Automation Compatible – Bar coded and compatible with The Automation Partnership SelecT™ and CompacT™ SelecT™ cell culture systems with an upgrade
Learn More

Video Series

How To Use HYPERFlask Vessels

Step 1: Seeding

Step 1: Seeding

Step 1: Seeding

Learn how to seed your vessel.

Learn how to seed your vessel.

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Step 2: Emptying

Step 2: Emptying

Step 2: Emptying

Learn how to empty your vessel.

Learn how to empty your vessel.

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Step 3: Rinsing

Step 3: Rinsing

Step 3: Rinsing

Learn how to rinse your vessel.

Learn how to rinse your vessel.

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Step 4: Harvesting

Step 4: Harvesting

Step 4: Harvesting

Learn how to harvest your cells.

Learn how to harvest your cells.

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Video Series

How To Use HYPERStack Vessels

Step 1: Aseptic Connect/Disconnect

Step 1: Aseptic Connect/Disconnect

Step 1: Aseptic Connect/Disconnect

Learn how to perform an aseptic connect and disconnect.

Learn how to perform an aseptic connect and disconnect.

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Step 2: Fill

Step 2: Fill

Step 2: Fill

Learn how to fill your vessel.

Learn how to fill your vessel.

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Step 3: Depressurize

Step 3: Depressurize

Step 3: Depressurize

Learn how to depressurize your vessel.

Learn how to depressurize your vessel.

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Step 4: Empty

Step 4: Empty

Step 4: Empty

Learn how to empty your vessel.

Learn how to empty your vessel.

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Step 5: Harvest

Step 5: Harvest

Step 5: Harvest

Learn how to harvest your cells.

Learn how to harvest your cells.

Watch Now

Featured Resources

Extracellular Vesicles: What They Are, Application Potential, and How to Scale

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Extracellular Vesicles: What They Are, Application Potential, and How to Scale

Mesenchymal stem cells offer promise across various applications in regenerative medicine, but they do have challenges. Can extracellular vesicles (EVs) tap into that promise with lower risk? New research indicates they could.

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The Growing Role of MSCs in Regenerative Medicine

The Growing Role of MSCs in Regenerative Medicine

Learn more about the growing role of MSCs in regenerative medicine, including current challenges and potential tools and technologies to help overcome them.

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Adherent vs. Suspension Advantages & Disadvantages

Adherent vs. Suspension Advantages & Disadvantages

Use this infographic to explore which cell culture platform is right for your lab.

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Synthemax

Using HYPERStack and Microcarriers for Scale-Up and Production

Study the efficacy of generating viral particles using Corning HYPER technology and the use of enhanced attachment microcarrier beads on cell lines typically used in vaccine production.

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Extracellular Vesicles

Extracellular Vesicles

Corning offers a line of products designed for large-scale of stem cell-derived extracellular vesicles (EVs) to impact regenerative medicine and the treatment of inflammatory conditions.

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Taking the HYPER Technology Road to 300,000 cm2 +

Taking the HYPER Technology Road to 300,000 cm2 +

This infographic provides a roadmap for scaling up and out with HYPER technology.

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The Race to Billions: How Amplifying Adherent Cultures Can Get You There

The Race to Billions: How Amplifying Adherent Cultures Can Get You There

Learn more about how adherent culture platforms can help you scale-up, while trimming time and costs with high-efficiency output.

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Cell Therapy Ebook

Ebook: Cell Therapy

This ebook provides an overview of key considerations and technologies for cell therapy production and developing a therapeutic candidate from research scale to clinical or commercial manufacturing.

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STACK FACTS: Scaling Up from Research to Clinical Applications

STACK FACTS: Scaling Up from Research to Clinical Applications

Use this guide to help you choose your ideal Corning vessel for scaling up. Whatever your work requires, Corning’s got you covered.

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Application Notes

HYPERStack Vessel

Adipose-derived Human Mesenchymal Cell Production in HYPERStack 36-layer Vessels

Discover  the utility of the HYPERStack 36-layer cell culture vessel as a tool to scale up and meet the growing demand of adipose-derived MSCs.

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HYPERFlask Vessel

Increased Cell Yields for Cell-based Assays with HYPERFlask Vessel

See how the HYPERFlask vessel increases yields for cell-based assays without affecting cell behavior.

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HYPERStack Vessel

Large Scale Transient Transfection for the Production of Lentiviral Vectors using the HYPERStack Vessel

Learn how the HYPERStack vessel can produce a superior LV titer compared to traditional stacked layer cell culture vessels.

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HYPERFlask Vessel

Large-scale Production of Influenza A Virus Using HYPERFlask Vessel

See how the HYPERFlask vessel, with 10 times more cell growth area than a standard T-175 flask, increases scale-up efficiency by using a single vessel compared to multiple flasks.

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Lentiviral Particles

Generating Lentiviral Particles in the Corning HYPERStack Vessel

Corning researchers produced equivalent titers and higher yields of lentivirus in the HYPERStack vessel compared to standard rigid stacked vessels.

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HYPERFlask

Coating HYPERFlask with Collagen / Gelatin

Discover how to produce thin collagen / gelatin coatings to aid in cell attachment & spreading.

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How to Buy

Purchasing Options

Order Now

Order Now

Order Now

It’s easy to purchase Corning HYPER technology products online. Just browse our online catalog, and add products directly to your cart. Order direct with a credit card or use a purchase order if you have an account with Corning.

It’s easy to purchase Corning HYPER technology products online. Just browse our online catalog, and add products directly to your cart. Order direct with a credit card or use a purchase order if you have an account with Corning.

Distributors

Distributors

Distributors

Many distributors offer the Corning HYPER technology platform.

Many distributors offer the Corning HYPER technology platform.

Customer Service

Customer Service

Customer Service

If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.

If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.

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Falcon® Multi-Flask Vessel

Falcon® Multi-Flask Vessel

With an increased growth surface of 525 cm2 or 875 cm2, the Falcon Multi-flask is a stackable 3- or 5-layer vessel with the same footprint as a T-175 flask and the same proven tissue culture-treated surface as other Falcon flasks.

With an increased growth surface of 525 cm2 or 875 cm2, the Falcon Multi-flask is a stackable 3- or 5-layer vessel with the same footprint as a T-175 flask and the same proven tissue culture-treated surface as other Falcon flasks.

Bioprocess Products

Bioprocess Products

See our extensive selection of vessels, media, and surface treatments for scaling-up both anchorage-dependent and suspension cells.

Decrease the risk of contamination, eliminate the time and expense of sourcing and assembly, and improve productivity with a custom Corning closed system.

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