Corning has addressed the industry-wide shortage of vessels for adherent cell culture scale-out by dramatically increasing our manufacturing capacity for HYPERStack® cell culture vessels, one of the most efficient platforms for adherent cell culture available today. As a result, HYPERStack vessels are available for immediate shipment.
Overview
Scale-up with Corning HYPER technology.
Scale-up with Corning HYPER technology.
The next generation High Yield PERformance (HYPER) technology lets you grow large quantities of adherent cells in a compact space. The cell production technology uses a unique ultra-thin gas-permeable film to eliminate the air gap within the vessel. This results in a substantial increase in cell growth surface area compared to traditional vessels of comparable cubic footprint.
Vessels with Corning’s HYPER technology are available for research applications (Corning HYPERFlask®) and biopharmaceutical production (Corning HYPERStack®). The benefits include:
- Higher total cell yields than vessels with similar spatial footprints
- Similar cell morphology, phenotype, and growth compared to traditional vessels
- Closed system design ideal for large scale cells, protein therapeutics, vaccine, and virus production including those targeting Coronavirus and COVID-19 (HYPERStack).
Ebook: Improving Scale-up Efficiency with Corning® HYPER Technology
A compilation of research experiences in stem cell, viral vector and vaccine production.
Do more with Corning HYPERStack Cell Culture Vessels
See how this closed system offers more surface area within a compact footprint.
HYPER Platform Products
HYPERStack Cell Culture Vessel
HYPERStack Cell Culture Vessel
Learn MoreUtilizing Corning HYPER technology - the ultra-thin gas-permeable film - allows the Corning HYPERStack cell culture vessel to be the most efficient, scalable cell culture vessel for adherent cell culture available today.
- More cells – provides up to 5X the growth surface area of a traditional cell culture vessel of comparable footprint
- Closed system – no open fluid manipulations
- Scalable product – multiple size offerings support scale-up and scale-out
- Ergonomic design – easier manipulation with handling accessories and equipment
- Fixed media volume – 0.2 mL/cm2 fills vessel for less volumetric waste
Utilizing Corning HYPER technology - the ultra-thin gas-permeable film - allows the Corning HYPERStack cell culture vessel to be the most efficient, scalable cell culture vessel for adherent cell culture available today.
- More cells – provides up to 5X the growth surface area of a traditional cell culture vessel of comparable footprint
- Closed system – no open fluid manipulations
- Scalable product – multiple size offerings support scale-up and scale-out
- Ergonomic design – easier manipulation with handling accessories and equipment
- Fixed media volume – 0.2 mL/cm2 fills vessel for less volumetric waste
HYPERFlask Cell Culture Vessel
HYPERFlask Cell Culture Vessel
Learn MoreThe Corning HYPERFlask cell culture vessel offers 1720 cm² growth area in the footprint of a traditional 175 cm² flask by using a multilayered, gas-permeable growing surface for efficient gas exchange.
- Innovative Design – 10 interconnected polystyrene growth surfaces
- Optimal Growth – Corning CellBIND® Surface treated gas-permeable polystyrene for superior cell attachment and growth
- Increase Cell Yield – 10-fold higher cell yields increases productivity and capacity and reduces processing time and incubator space
- Automation Compatible – Bar coded and compatible with The Automation Partnership SelecT™ and CompacT™ SelecT™ cell culture systems with an upgrade
The Corning HYPERFlask cell culture vessel offers 1720 cm² growth area in the footprint of a traditional 175 cm² flask by using a multilayered, gas-permeable growing surface for efficient gas exchange.
- Innovative Design – 10 interconnected polystyrene growth surfaces
- Optimal Growth – Corning CellBIND® Surface treated gas-permeable polystyrene for superior cell attachment and growth
- Increase Cell Yield – 10-fold higher cell yields increases productivity and capacity and reduces processing time and incubator space
- Automation Compatible – Bar coded and compatible with The Automation Partnership SelecT™ and CompacT™ SelecT™ cell culture systems with an upgrade
Video Series
How To Use HYPERFlask Vessels
Step 1: Seeding
Step 1: Seeding
Learn how to seed your vessel.
Learn how to seed your vessel.
Watch Now
Step 2: Emptying
Step 2: Emptying
Learn how to empty your vessel.
Learn how to empty your vessel.
Watch Now
Step 3: Rinsing
Step 3: Rinsing
Learn how to rinse your vessel.
Learn how to rinse your vessel.
Watch Now
Step 4: Harvesting
Step 4: Harvesting
Learn how to harvest your cells.
Learn how to harvest your cells.
Watch NowVideo Series
How To Use HYPERStack Vessels
Step 1: Aseptic Connect/Disconnect
Step 1: Aseptic Connect/Disconnect
Learn how to perform an aseptic connect and disconnect.
Learn how to perform an aseptic connect and disconnect.
Watch Now
Step 3: Depressurize
Step 3: Depressurize
Learn how to depressurize your vessel.
Learn how to depressurize your vessel.
Watch Now
Step 4: Empty
Step 4: Empty
Learn how to empty your vessel.
Learn how to empty your vessel.
Watch Now
Step 5: Harvest
Step 5: Harvest
Learn how to harvest your cells.
Learn how to harvest your cells.
Watch NowFeatured Resources
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Extracellular Vesicles: What They Are, Application Potential, and How to Scale
Watch Now: Extracellular Vesicles: What They Are, Application Potential, and How to ScaleMesenchymal stem cells offer promise across various applications in regenerative medicine, but they do have challenges. Can extracellular vesicles (EVs) tap into that promise with lower risk? New research indicates they could.
The Growing Role of MSCs in Regenerative Medicine
Learn More: The Growing Role of MSCs in Regenerative MedicineLearn more about the growing role of MSCs in regenerative medicine, including current challenges and potential tools and technologies to help overcome them.
Adherent vs. Suspension Advantages & Disadvantages
Download: Adherent vs. Suspension Advantages & DisadvantagesUse this infographic to explore which cell culture platform is right for your lab.
Using HYPERStack and Microcarriers for Scale-Up and Production
Download: Using HYPERStack and Microcarriers for Scale-Up and ProductionStudy the efficacy of generating viral particles using Corning HYPER technology and the use of enhanced attachment microcarrier beads on cell lines typically used in vaccine production.
Extracellular Vesicles
Learn More: Extracellular VesiclesCorning offers a line of products designed for large-scale of stem cell-derived extracellular vesicles (EVs) to impact regenerative medicine and the treatment of inflammatory conditions.
Taking the HYPER Technology Road to 300,000 cm2 +
Download: Taking the HYPER Technology Road to 300,000 cm2 +This infographic provides a roadmap for scaling up and out with HYPER technology.
The Race to Billions: How Amplifying Adherent Cultures Can Get You There
Download: The Race to Billions: How Amplifying Adherent Cultures Can Get You ThereLearn more about how adherent culture platforms can help you scale-up, while trimming time and costs with high-efficiency output.
Ebook: Cell Therapy
Download: Ebook: Cell TherapyThis ebook provides an overview of key considerations and technologies for cell therapy production and developing a therapeutic candidate from research scale to clinical or commercial manufacturing.
STACK FACTS: Scaling Up from Research to Clinical Applications
Download: STACK FACTS: Scaling Up from Research to Clinical ApplicationsUse this guide to help you choose your ideal Corning vessel for scaling up. Whatever your work requires, Corning’s got you covered.
Application Notes
How to Buy
Purchasing Options
Product Catalog
Product Catalog
Browse our online catalog for the latest product information.
Browse our online catalog for the latest product information.
Distributors
Distributors
Many distributors offer the Corning HYPER technology platform.
Many distributors offer the Corning HYPER technology platform.
Customer Service
Customer Service
If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.
If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.
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Corning Media, Sera, and Reagents
Corning Media, Sera, and Reagents
Ensure consistent, reproducible results with high-performance media, sera, and reagents from Corning.
Ensure consistent, reproducible results with high-performance media, sera, and reagents from Corning.
Falcon® Multi-Flask Vessel
Falcon® Multi-Flask Vessel
With an increased growth surface of 525 cm2 or 875 cm2, the Falcon Multi-flask is a stackable 3- or 5-layer vessel with the same footprint as a T-175 flask and the same proven tissue culture-treated surface as other Falcon flasks.
With an increased growth surface of 525 cm2 or 875 cm2, the Falcon Multi-flask is a stackable 3- or 5-layer vessel with the same footprint as a T-175 flask and the same proven tissue culture-treated surface as other Falcon flasks.
Bioprocess Products
Bioprocess Products
See our extensive selection of vessels, media, and surface treatments for scaling-up both anchorage-dependent and suspension cells.
Decrease the risk of contamination, eliminate the time and expense of sourcing and assembly, and improve productivity with a custom Corning closed system.
