Tissue Fractions | Advanced Optics | Corning

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One Proven Brand, from Metabolism Studies Through

Enhance the results of your ADME metabolism-based assays with Corning® Gentest™ tissue fractions. By choosing these high quality reagents, you'll have the tools you need to address differences in populations, catalytic activity, and genetic polymorphism. And by standardizing on the Corning Gentest brand, your organization will have the full complement of reagents, chemicals, buffers, media, antibodies, and ancillary products it requires to help put promising new drug therapies on a sure path to full commercialization.

Sound decision making depends upon having the full range of high-quality tissue fractions you need to perform metabolism-based assays that deliver consistent, reproducible data.
 

Corning Gentest Tissue Fractions

Animal and Specialty Tissue Fractions

Animal Tissue Fractions: Equivalent Quality, Reproducibility, and Characterization as Corning Human Liver Products

Like human liver products, animal tissue fractions are well suited for metabolic stability testing, metabolite identification, and mechanistic studies. They can be used to quickly generate such metabolism data as compound stability and metabolite formation.

  • Large lots for maximum product availability
  • Pooled animal donors, minimizing lot-to-lot variability to better represent the average of the species
     
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Specialty Tissue Fractions: Formulated to Address Metabolic Differences in Population Groups

Our portfolio includes:

  • Pooled single gender HLMs, formulated from five or more donors
  • Mixed pool CMV (cytomegalovirus) negative HLMs—formulated from male and female donors testing negative serologically and with PCR-based testing
  • Mixed pooled human intestinal microsomes—prepared from both the duodenum and jejunum sections of the small intestine for intestinal metabolism testing of CYP2C9, 3A4, 2J2/4F12, UGT1A, and carboxylesterase
  • Corning Gentest single donor HLM pools, offering the flexibility to select from a broad range of donors and CYP catalytic activity levels
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What’s New

Featured Products, Resources, and More

Optimizing Donor Number for Consistent Pooled HLMs

Optimizing Donor Number for Consistent Pooled HLMs

An analysis of the CYP activity distributions for over 300 donors.

Optimizing Donor Number for Consistent Pooled Human Liver Microsomes

Based on a detailed statistical analysis of the variability in indi¬vidual CYP activity levels for over 300 donors, the authors of this study conclude that the number of donors in pooled HLMs should be increased more than two-fold. A donor number of 150 appears to be a sweet spot providing low CVs for the major CYPs such that the variability in the HLM product is well below the overall assay variability. This conclusion has led to the decision to develop and commercialize Corning UltraPool HLM 150, a pooled HLM product comprised of 75 male donor livers and 75 female donor livers.

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UltraPool HLM 150 Characterization

UltraPool HLM 150 Characterization

Get detailed characterization data on Corning UltraPool HLM 150.

Corning UltraPool HLM 150 Characterization

This technical document provides detailed charts and graphics demonstrating the characterization of Corning UltraPool HLM 150, the first commercially available large donor pool.

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Differential Time- and NADPH-dependent Inhibition

Differential Time- and NADPH-dependent Inhibition

Learnings and conclusions from a reversible inhibition protocol.

Differential Time- and NADPH-dependent Inhibition of CYP2C19 by Enantiomers of Fluoxetine

This application note highlights a study in which its authors compared fluoxetine, its (R)- and (S)-enantiomers, ticlopidine, and the reversible CYP2C19 inhibitor S-benzylnirvanol. In a reversible inhibition protocol (30 minute preincubation with liver microsomes without NADPH), they found (R)-, (S)-, and racemic fluoxetine to be moderate inhibitors with IC50 values of 17, 67, and 27 μM, respectively, among several other important conclusions.

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FAQs: Tissue Fractions

FAQs: Tissue Fractions

Get the answers you need to take advantage of our full line of Corning Gentest tissue fractions.

Frequently Asked Questions: Corning Gentest Tissue Fractions

From storage methods and stability questions to the best method to mix microsomal suspensions, get answers to commonly asked questions about using Corning Gentest tissue fractions to support all of your metabolism-based assays.

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Featured Products, Resources, and More

Corning Gentest Contract Research Services

Corning Gentest Contract Research Services

Get expert assistance from expert ADME Study Directors.

Take your research to the next level with expert assistance from our Contract Research Services

Need one-on-one specialized research support? Our ADME Study Directors stand ready to become an extension of your teamor your virtual partnerto help strengthen your ability to meet your drug discovery and pre-clinical goals. Corning Study Directors are knowledgeable in ADME research and regulatory compliance and stay current with rapidly changing technological and regulatory developments.

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ADME Technical Resources

ADME Technical Resources

ADME Technical Resources

We provide a range of technical materials (e.g., application notes, bulletins, instruction manuals, and selection and use guides) that support our products and key applications.

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