Support the propagation and differentiation of a wide range of stem, progenitor, and primary cell types with Corning® ECM Mimetic surfaces and substrates. Made with biologically active, synthetic, or recombinant animal-free peptides and proteins, our ECM mimetic and advanced surfaces enable optimal cell binding and signaling in a broad range of serum-free, xeno-free, and animal-free media formulations.
cGMP-compliant manufacturing and animal-free traceability — manufactured in animal-free, cGMP compliant facilities that meet ISO 9001:2008 and 13485:2012 standards using animal-free components, Corning ECM mimetic and recombinant laminin surfaces mitigate variability and risk of contamination from adventitious organisms common to animal-sourced material.
Scalable, pre-coated, room-temperature-stable vessel platforms — streamline the cell expansion workflow by removing the need for tedious, time consuming, and inconsistent self-coating protocols. Pre-coated recombinant laminin-521, Fibronectin peptide, Collagen I peptide, or Corning Synthemax® peptide surfaces are ready to use, stable and are available on multilayered vessels, such as the Falcon® Multi-Flask and Corning CellSTACK® vessels with closed system options.
ECM Mimetic and Advanced Surfaces
ECM Mimetic and Advanced Surfaces
Obtain unique, functional surface activity to enable a range of specialized cell expansion and assay applications.
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ECM Mimetic and Defined Surfaces
Learn More About ECM Mimetic and Advanced Surfaces
Corning® PureCoat™ ECM Mimetic Cultureware
Corning® PureCoat™ ECM Mimetic Cultureware
Support your clinical research with the scientifically defined, natural performance of Corning®.
Support your clinical research with the scientifically defined, natural performance of Corning®.
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rLaminin Surface
rLaminin Surface
Support long-term self-renewal of human pluripotent stem cells (hPSC) and neural stem cells (NSCs).
Support long-term self-renewal of human pluripotent stem cells (hPSC) and neural stem cells (NSCs).
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Corning Synthemax Surface
Corning Synthemax Surface
Support and enhance stem cell adhesion and expansion with Corning Synthemax vitronectin substrate.
Support and enhance stem cell adhesion and expansion with Corning Synthemax vitronectin substrate.
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Ultra-Low Attachment Surface
Ultra-Low Attachment Surface
Enable 3D Spheroid Formation with Corning Ultra-Low Attachment Surface.
Enable 3D Spheroid Formation with Corning Ultra-Low Attachment Surface.
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Osteo Assay Surface
Osteo Assay Surface
Mimic native bone with the Corning® osteo assay surface and create a more life-like.
Mimic native bone with the Corning® osteo assay surface and create a more life-like.
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ECM Mimetic and Defined Surfaces Product Details and Applications
*SF = serum-free media, XF = xeno-free media, AF = animal-free media.
*SF = serum-free media, XF = xeno-free media, AF = animal-free media.
| Corning PureCoat ECM Mimetic Fibronectin Peptide | Corning PureCoat ECM Mimetic Collagen I Peptide | Corning Synthemax Vitronectin Peptide | Corning rLaminin-521 (Human) |
Formats (Cat. No./Description/Qty.) | 356240 | 6 well plate 356241 | 24 well plate 356242 | T-75 Flask 356243 | T-175 Flask 356244 | Multi-Flask 3-layer 356245 | Multi-Flask 5- | 356270 | 6 well plate 356271 | 24 well plate 356272 | T-75 Flask 356273 | T-175 Flask 356274 | Multi-Flask 3-layer 356275 | Multi-Flask 5-layer
| 3535 | 10 mg (self-coat peptide) | 354221 | 100 µg
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Options | Multiple Well Plates: 6 well and 24 well Flasks: T-75, T-175 Multi-layer Flasks: 3- and 5-layer Corning CellSTACK: 2-, 5-, and 10-layer | Multiple Well Plates: 6 well and 24 well Flasks: T-75, T-175 Multi-layer Flasks: 3- and 5-layer | Pre-coated on microcarriers Custom pre-coated vessels available | Please inquire about pre-coated vessel options. |
Application | Ready-to-use cultureware suitable as a replacement for natural, selfcoated Fibronectin for adult stem, progenitor, and primary cell types in defined media environments | Ready-to-use cultureware suitable as a replacement for natural, selfcoated Collagen I for adult stem, progenitor, and primary cell types in defined media environments | A flexible coating substrate for the culture of hPS, adult, and progenitor cell types in defined media environments | A robust, animal component-free substitute enabling ROCK-independent, single cell passaging of pluripotent stem cells in defined media environments |
Surface Technology | Covalently bound, synthetic peptide containing the RGD sequence and flanking Fibronectin sequences | Covalently bound, synthetic peptide containing the GFOGOR sequence and flanking Collagen I sequences | Passively coated, synthetic peptide acrylate polymer containing the RGD sequence and flanking Vitronectin sequences | Passively coated, full length recombinant Laminin protein |
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Shelf-life | 18 months at room temperature | 18 months at room temperature | 24 months for self-coat peptide when stored at -20°C
12 months for pre-coated cultureware when stored at 4°C | 24 months when stored at -20°C |
Technical Expertise
Technical Expertise
了解更多From protocols and webinars to onsite technical demos and custom capabilities, our experts are available to get your research up and running, with complete support along the way.
From protocols and webinars to onsite technical demos and custom capabilities, our experts are available to get your research up and running, with complete support along the way.
Innovation
Beyond Bisphosphonates: Inhibiting Bone Resorption Without Impacting Bone Rebuilding
Taking advantage of an advanced cell culture surface developed by Corning, scientists were able to identify cellular activity that revealed a deeper look into how osteoclasts work to facilitate bone resorption. Their research is providing vital information that may lead to the development of novel therapeutics offering advantages over treatments currently available for bone loss.
Applications and Use
ECM Mimetic and Advanced Surfaces in Action
Technical Resources
Technical Resources
Download resources including protocols, manuals, posters and presentations.
Download resources including protocols, manuals, posters and presentations.
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Neurobiology
Neurobiology
In vitro culture of neurons and neuronal stem cells calls for defined culture surfaces that enable successful attachment and differentiation.
In vitro culture of neurons and neuronal stem cells calls for defined culture surfaces that enable successful attachment and differentiation.
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Adherent Cells Culture
Synthetic Surfaces for Serum-free Culture of Adherent Cells
See how both Corning PureCoat ECM mimetic cultureware fibronectin peptide and Corning PureCoat ECM mimetic cultureware collagen peptide supported enhanced proliferation of Vero cells in serum-free, low-protein medium when compared to a Tissue Culture (TC)-treated surface.
See how both Corning PureCoat ECM mimetic cultureware fibronectin peptide and Corning PureCoat ECM mimetic cultureware collagen peptide supported enhanced proliferation of Vero cells in serum-free, low-protein medium when compared to a Tissue Culture (TC)-treated surface.
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Stem Cell Therapy
Stem Cell Therapy
Stem cell therapy holds great promise, and Corning is committed to enabling the advancement of this area of research with specialized vessels, surfaces, and media to keep pushing the boundaries of what is possible.
Stem cell therapy holds great promise, and Corning is committed to enabling the advancement of this area of research with specialized vessels, surfaces, and media to keep pushing the boundaries of what is possible.
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Featured Products, Resources, and More
Simplify PSC Expansion with rLaminin-521, the Next-gen hPSC Surface
Simplify PSC Expansion with rLaminin-521, the Next-gen hPSC Surface
Streamline your pluripotent stem cell (PSC) culture workflow with rLaminin surface, a robust, animal component-free substitute enabling ROCK-independent, single cell passaging of pluripotent stem cells in defined media environments
Available on dishes, flasks, and well plates, our Ultra-Low Attachment surface is a unique hydrogel coating that greatly helps prevents cellular attachment.
The Ultra-Low Attachment surface is designed for:
- Maintaining cells in a suspended, unattached state.
- Preventing stem cells from attachment-mediated differentiation.
- Preventing anchorage-dependent cells from dividing.
- Reducing binding of attachment and serum proteins to the substrate.
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