Cancer Research Products | Cancer Cell Research Resources | Corning

Cancer research is complex. Finding a trusted, experienced partner is simple.

Unlocking the complexities of cancer is an ongoing challenge. Luckily, countless individuals are determined to discover new and better ways to more effectively prevent, fight or even cure cancer.  

Corning supports this important research with reliable lab products that deliver consistent, repeatable results. Matrigel® matrix, Matrigel matrix-3D plates, defined ECMs and hydrogels, BioCoat®, Transwell® and FluoroBlok™ permeable supports, Elplasia® plates and flasks, and spheroid microplates are just a few Corning products being used in cutting edge cancer research studies.

Whether your research is focused on tumor formation, angiogenesis, or intravasation/metastasis/extravasation, drug discovery or studying the tumor microenvironment, we have the knowledge and experience to simplify product selection, provide technical support, and set your research up for success – right from the start.

The Progression of Cancer and How to Study it In Vitro

The Progression of Cancer and How to Study it In Vitro

Tumorigenesis is a complex process involving cell mutagenesis and the transformation of cells from normal to aberrant proliferative behavior. Tumor cells escape the normal constraints on cell division and then progress through the stages of uncontrolled cell proliferation and tumor formation. All the cells derived from the parent tumor cells display tumorigenic behavior and contribute to the tumor mass as it grows. Tumor growth and survival is dependent on the process of angiogenesis, which provides the tumor with a vascular network and blood supply that effectively feeds the tumor cells. The resulting tumor may remain within the tissue of origin (referred to as in situ cancer) or spread to other tissues and organs via the process of metastasis (referred to as invasive cancer). Understanding how likely a cancer is to be invasive is important as tumor metastasis is considered the leading cause of death in cancer patients1. Transwell permeable supports have traditionally been used to better understand cell invasion as cells can crawl through the pores of inserts that have been coated with extracellular matrices (ECMs) and or cells to better replicate the path cancer cells would have to take to get to another tissue2. Recently, spheroid models are being utilized to better understand tumor invasion and angiogenesis mechanisms as spheroids can be easily formed on low attachment plates and embedded in ECMs3.With imaging technology, like confocal imagers, the rate of invasion or angiogenesis can be studied.

References:

1. González-Orozco, Juan Carlos, et al. “In Vitro Models for Studying Tumor Progression.” Methods in molecular biology (Clifton, N.J.) vol. 2174 (2021): 193-206. doi:10.1007/978-1-0716-0759-6_12

2. Justus, Calvin R, et al. “Transwell In Vitro Cell Migration and Invasion Assays.” Methods in molecular biology (Clifton, N.J.) vol. 2644 (2023): 349-359. doi:10.1007/978-1-0716-3052-5_22

3. Chen, Yin-Quan, et al. "Early stage mechanical remodeling of collagen surrounding head and neck squamous cell carcinoma spheroids correlates strongly with their invasion capability." Acta biomaterialia 84 (2019): 280-292.

Cancer Research Featured Resources

Tumor Formation

Tumor Formation

Overview

The process of tumorigenesis begins when a normal cell undergoes mutational changes that initiate and promote the transformation to a tumor cell. As tumor cells engage in uncontrolled proliferation, the tumorigenic cell population can form a tumor mass at the site or tissue of origin.

Featured Products:

Featured Resources: Tumor Formation

Featured Resources: Angiogenesis

Intravasation/Metastasis/Extravasation

Intravasation/Metastasis/Extravasation

Overview

Metastasis via Intravasation: During the intravasation process, tumor cells exit the tumor of origin and invade through the basement membrane and vessel walls into nearby lymphatic or blood vessels.

Secondary Tumor Formation via Extravasation: During extravasation, circulating tumor cells exit the lymphatic or blood vessels by invading through vessel walls and basement membrane into a new tissue or organ.

Featured Assays:

Featured Resources: Intravasation/Metastasis/Extravasation

Support

Scientific Support–Setting a New Industry Standard

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Corning Matrigel Matrix

Corning Matrigel Matrix

Corning Matrigel Matrix

Better mimic in vivo environments for 2D and 3D cell culture applications with Corning Matrigel Matrix.

Better mimic in vivo environments for 2D and 3D cell culture applications with Corning Matrigel Matrix.

Corning Elplasia® 12K Flask

Corning Elplasia® 12K Flask

Corning Elplasia® 12K Flask

Culture thousands of spheroids in a convenient flask format.

Culture thousands of spheroids in a convenient flask format.

Elplasia® Plates

Elplasia® Plates

Elplasia® Plates

Elplasia plates generate, culture, and analyze your spheroids all in a standard plate footprint.

Elplasia plates generate, culture, and analyze your spheroids all in a standard plate footprint.