The tumor metastasis process is multistep and includes local invasion, intravasation, transport, extravasation, and colonization.
Metastasis via Intravasation: During the intravasation process, tumor cells exit the tumor of origin and invade through the basement membrane and vessel walls into nearby lymphatic or blood vessels.
Secondary Tumor Formation via Extravasation: During extravasation, circulating tumor cells exit the lymphatic or blood vessels by invading through vessel walls and basement membrane into a new tissue or organ. These processes leave cancer cells vulnerable to circulating immune cells, mechanical forces and anoikis6. Yet, even with these challenges, cancer cells have found ways to protect themselves. Understanding these protective mechanisms might help us one day find ways to counter them.
Corning supports tumor metastasis research with lab products that deliver consistent, repeatable results. Corning Matrigel® matrix 3d plates and Corning BioCoat®, fluoroblok, and transwell permeable supports are just a few of Corning products being used in research studies.
We have the knowledge and experience to simplify lab product selection, provide technical support, and set your research up for success – right from the start.
References:
6. Strilic, Boris and Stefan Offermanns. "Intravascular survival and extravasation of tumor cells." Cancer cell 32.3 (2017): 282-293.
