The process of tumorigenesis begins when a normal cell undergoes mutational changes that initiate and promote the transformation to a tumor cell. As tumor cells engage in uncontrolled proliferation, the tumorigenic cell population can form a tumor mass at the site or tissue of origin.
It is well known that the two-dimensional (2D) cell culture environments do not accurately reflect all of the complexity of a three-dimensional (3D) tumor. Three-dimensional spheroid models better replicate the complexities and heterogeneity of a solid tumor with the formation of naturally occurring gradients such as with nutrients, oxygen, and waste products4. And, 3D tumor spheroids can be easily generated in a variety of ways including using hydrogels, low attachment plates, and suspension culture. This makes 3D tumor models highly amenable to all areas of drug discovery from basic research to drug screening.
Corning supports the research of tumorigenesis with reliable lab products that deliver consistent, repeatable results. Corning Matrigel® matrix, ideal for creating 3d organoid models, Elplasia® plates and flasks for screening applications, as well as cancer/tumor biology, spheroid microplates and spheroid matrix kits are just a few of Corning products being used in research studies.
We have the knowledge and experience to simplify lab product selection, provide technical support, and set your research up for success – right from the start.
References:
4. Benien, Paru, and Archana Swami. "3D tumor models: history, advances and future perspectives." Future oncology 10.7 (2014): 1311-1327.
