疫苗生产_大规模细胞培养仪器和产品

概述

利用康宁HYPER技术实现大规模培养

借助新一代HYPER（High Yield PERformance）技术，您可以在紧凑的空间内实现贴壁细胞大规模培养。细胞生产采用独特的透气膜技术，去除了器皿内的空气间隙。相比传统器皿，可大幅增加细胞生长面积。

采用康宁HYPER技术的器皿可用于研发 (康宁HYPERFlask®) 和生物制药生产 (康宁HYPERStack®)。其优势包括：

相比同等体积的其他培养器皿，总细胞产量更高
细胞形态、表型和生长与传统器皿类似
HYPERStack封闭系统设计，适用于细胞、治疗性蛋白、疫苗和病毒的大规模生产，包括冠状病毒和COVID-19 领域

Ebook: Improving Scale-up Efficiency with Corning^® HYPER Technology

A compilation of research experiences in stem cell, viral vector and vaccine production.

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Do more with Corning HYPERStack Cell Culture Vessels

See how this closed system offers more surface area within a compact footprint.

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利用康宁HYPER技术提升大规模培养的效率

在干细胞、病毒载体和疫苗生产方面积累了丰富的研发经验。

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HYPER平台产品

HYPERStack Cell Culture Vessel

HYPERStack 超级细胞培养室

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康宁HYPERStack超级细胞培养室融合了康宁CellSTACK®细胞培养室和康宁HYPERFlask超级细胞培养瓶的优势。其将专有的透气膜技术应用到CellSTACK细胞培养室，是目前最高效且规模可扩展的贴壁细胞培养器皿。

更多细胞——相同体积下的细胞产量高2.5倍
封闭系统——无开放式液体操作
规模可扩展——提供多种尺寸
人体工程学设计——更易于操作
固定的培养基体积——0.2 mL/cm²，有助于实现最佳操作
创新组装——无粘合剂，低微粒
减少体积浪费——每个生长区域减少浪费，降低总成本

更多细胞——相同体积下的细胞产量高2.5倍
封闭系统——无开放式液体操作
规模可扩展——提供多种尺寸
人体工程学设计——更易于操作
固定的培养基体积——0.2 mL/cm²，有助于实现最佳操作
创新组装——无粘合剂，低微粒
减少体积浪费——每个生长区域减少浪费，降低总成本

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HYPERFlask Cell Culture Vessel

HYPERFlask 超级细胞培养瓶

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康宁HYPERFlask超级细胞培养瓶利用多层透气生长表面，实现高效的气体交换，其占用空间与传统175 cm²培养瓶相同，却可提供1720 cm²的细胞生长面积。

创新设计——10层互连的聚苯乙烯生长表面
最佳生长状态——经过康宁CellBIND® 表面处理的透气性聚苯乙烯表面，可实现极佳的细胞粘附和生长效果
细胞产量更高——细胞产量提高了10倍，有助于提升产率和产能，缩短流程时间，并节省培养箱空间
适合自动化操作——带条形码，升级后可与The Automation Partnership SelecT™ 和CompacT™ SelecT™ 细胞培养系统兼容

康宁HYPERFlask超级细胞培养瓶利用多层透气生长表面，实现高效的气体交换，其占用空间与传统175 cm²培养瓶相同，却可提供1720 cm²的细胞生长面积。

创新设计——10层互连的聚苯乙烯生长表面
最佳生长状态——经过康宁CellBIND® 表面处理的透气性聚苯乙烯表面，可实现极佳的细胞粘附和生长效果
细胞产量更高——细胞产量提高了10倍，有助于提升产率和产能，缩短流程时间，并节省培养箱空间
适合自动化操作——带条形码，升级后可与The Automation Partnership SelecT™ 和CompacT™ SelecT™ 细胞培养系统兼容

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Video Series

How To Use HYPERFlask Vessels

Step 2: Emptying

Learn how to empty your vessel.

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Step 3: Rinsing

Learn how to rinse your vessel.

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Step 4: Harvesting

Learn how to harvest your cells.

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Video Series

How To Use HYPERStack Vessels

Step 1: Aseptic Connect/Disconnect

Learn how to perform an aseptic connect and disconnect.

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Step 3: Depressurize

Learn how to depressurize your vessel.

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Step 4: Empty

Learn how to empty your vessel.

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Step 5: Harvest

Learn how to harvest your cells.

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Featured Resources

Ebook: Navigating Corning® HYPERStack® Cell Culture Vessels: A Collection of Application Notes

Corning’s High Yield PERformance (HYPER) platform – the Corning® HYPERStack® cell culture vessel – combines the best of two Corning products: the Corning CellSTACK® culture chamber and the Corning HYPERFlask® vessel.

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Next-Generation MSC Therapies: Advancing Treatment for GvHD

Learn about cutting-edge advancements in mesenchymal stromal cell (MSC) therapies for graft-versus-host disease (GvHD) and streamlined strategies for scaling up production.

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Extracellular Vesicles: What They Are, Application Potential, and How to Scale

Mesenchymal stem cells offer promise across various applications in regenerative medicine, but they do have challenges. Can extracellular vesicles (EVs) tap into that promise with lower risk? New research indicates they could.

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The Growing Role of MSCs in Regenerative Medicine

Learn more about the growing role of MSCs in regenerative medicine, including current challenges and potential tools and technologies to help overcome them.

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Adherent vs. Suspension Advantages & Disadvantages

Use this infographic to explore which cell culture platform is right for your lab.

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Using HYPERStack and Microcarriers for Scale-Up and Production

Study the efficacy of generating viral particles using Corning HYPER technology and the use of enhanced attachment microcarrier beads on cell lines typically used in vaccine production.

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Taking the HYPER Technology Road to 300,000 cm2 +

This infographic provides a roadmap for scaling up and out with HYPER technology.

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The Race to Billions: How Amplifying Adherent Cultures Can Get You There

Learn more about how adherent culture platforms can help you scale-up, while trimming time and costs with high-efficiency output.

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Ebook: Cell Therapy

This ebook provides an overview of key considerations and technologies for cell therapy production and developing a therapeutic candidate from research scale to clinical or commercial manufacturing.

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STACK FACTS: Scaling Up from Research to Clinical Applications

Use this guide to help you choose your ideal Corning vessel for scaling up. Whatever your work requires, Corning’s got you covered.

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Application Notes

Adipose-derived Human Mesenchymal Cell Production in HYPERStack 36-layer Vessels

Discover the utility of the HYPERStack 36-layer cell culture vessel as a tool to scale up and meet the growing demand of adipose-derived MSCs.

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Increased Cell Yields for Cell-based Assays with HYPERFlask Vessel

See how the HYPERFlask vessel increases yields for cell-based assays without affecting cell behavior.

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Large Scale Transient Transfection for the Production of Lentiviral Vectors using the HYPERStack Vessel

Learn how the HYPERStack vessel can produce a superior LV titer compared to traditional stacked layer cell culture vessels.

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Large-scale Production of Influenza A Virus Using HYPERFlask Vessel

See how the HYPERFlask vessel, with 10 times more cell growth area than a standard T-175 flask, increases scale-up efficiency by using a single vessel compared to multiple flasks.

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