From COVID to chronic infections to cancer, stem cell-derived extracellular vesicles (EVs) have the potential to change the landscape of regenerative medicine and the treatment of inflammatory conditions. Though still in early-stage research, work with EVs in the field already appears to hold great promise.
Based on studies with similar or sometimes potentially better therapeutic capacity as compared to stem cells, extracellular vesicles also offer the advantages of being non-immunogenic, able to bypass the blood-brain barrier, and their tropism.
But in order to make these potential therapies accessible, there is a need for optimized, large-scale EV production methods. Corning offers a line of products designed for large-scale cell culture applications. From the Corning® CellCube® and Corning CellSTACK® cell culture chambers, to the Corning HYPERFlask® and HYPERStack® vessels, these products allow the culture of a high volume of cells in a small footprint.
In addition to optimizing production, precise quantification and characterization of EVs remain critical for advancing both fundamental research and clinical applications. The Corning Videodrop provides a seamless, label-free method for swiftly measuring nanoparticle size and concentration. Leveraging interferometric light microscopy Videodrop allows for immediate, high-resolution assessment of EVs while requiring minimal sample handling. This innovative technology streamlines EV characterization, promoting increased reproducibility and reliability in research and therapeutic settings alike.
