By choosing Corning® Gentest™ tissue fractions, you will be able to conduct preclinical metabolism studies to predict the toxicity and pharmacokinetic properties of a drug compound, including metabolic stability, drug-drug interactions, reaction phenotyping, and metabolite identification. Our broad selection of liver and intestinal tissue fractions are highly characterized for important metabolizing enzymes such as CYPs, UGTs, and other enzymes. The fractions are offered as pooled or as single donors.
The pooled donors represent an average profile of catalytic activities from many individuals and are most suited for controlling the inter-individual variability in quantitative studies of metabolism. The Corning UltraPool™ HLM 150 is the first commercially available large donor pool. This product better represents the average patient population and known CYP polymorphisms, enabling consistent experimental results in multi-year programs, and offering a time savings by reducing the time required to qualify new lots of HLMs.
The single donor HLM pools offer activity levels from high to low representing the heterogeneity of expression of individual P450s found in the human population. These products provide flexibility to select from a broad range of donors at different CYP catalytic activity levels and enable to study the metabolism of specific CYPs and to phenotype and correlate CYP activities.
Many steps are taken during the manufacture of all Corning Gentest Tissue Fraction products to ensure quality and to reduce lot-to-lot variability. Corning adheres to high ethical standards and strict traceability for obtaining human materials and only sources from US-based Organ Procurement Organizations. High safety standards are also followed including serological testing prior to acceptance, followed by PCR testing for HIV I/II, Hepatitis B, Hepatitis C, and HTLV - I/II and syphilis.