Organoid Models | 3D Organoid Culture | Corning

Explore Organoid Model Environments

Explore Organoid Model Environments

Organoids are generated from both pluripotent stem cells (PSCs) and adult stem cells (ASCs). Self-renewal and differentiation of stem cells is influenced by growth factors and extracellular matrices (ECM) that provide the required scaffold to support cell attachment and growth during organoid formation. Hydrogels such as Corning Matrigel® Matrix and Corning® Collagen are popular scaffold choices to support cell expansion in organoid cultures.

Stem cells and/or organ progenitors from normal or diseased tissue can be mixed with Matrigel matrix or Collagen to create mini-organs of the kidney, thyroid, liver, brain, lung, intestine, prostate, and pancreas. Organoids support advancements in the study of organogenesis, disease modeling, and subsequent patient-specific therapies.  For example, the combination of genome editing using CRISPR-Cas9 and organoid cultures allows researchers to evaluate DNA repair of patient-specific mutations found in certain cancers and perform genetic screens. Hydrogels such as Collagen and Matrigel Matrix can be used as bio-inks to allow precise positioning and embedding of living cells/organoids during 3D bioprinting.  Organoids are also being used as physiologically relevant models for the development of new therapeutic drug candidates.

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e-Books Available for Download

Organoids

3D Model Systems: Spheroids, Organoids and Tissue Models

Spheroids, organoids & more complex 3D systems have been invaluable to research. Download this guide demystifying 3D models with helpful tips & techniques to set your 3D culture up for success.

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Organoid

e-Book Download: Expert Guide to Advanced 3D Cell Culture

Download this e-book to learn more about 3D techniques used in basic research, as well as translational and clinical applications.

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Ultimate Guide to Matrigel

Ultimate Guide to Matrigel

Access facts, tips, and expert advice on the most widely used ECM in scientific research.

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Applications

Organoid Model Applications

Organoid Model Applications

  

Publications

Supporting Publications for Organoid Culture

Supporting Publications for Organoid Culture

Ask the Expert: Using Organoids for Disease Modeling

See common questions and answers on culturing organoids from a team of scientific experts.

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Cancer Phenotypes

Discover research on organoid cultures for the analysis of cancer phenotypes.

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Engineering Stem Cell Organoids

Learn more about basic approaches to generate stem cell-based organoids, their advantages and limitations, and how bioengineering strategies can be implemented.

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Disease Modeling

Discover research examining disease modeling in stem-cell derived 3D organoid systems.

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Organoids and Epithelial Translational Medicine

Learn more about the advantages of stem cell-derived organoid models over existing culture systems, as well as recent advances in epithelial tissue-specific organoids.

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Organoids, Disease Models and 3D Printing: The Challenges and Opportunities for 3D Cell Culture

Learn about the advantages of culturing cells in three dimensions over traditional methods and look at the exciting new developments for the technology behind 3D cell culture.

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Support

Scientific Support–Setting a New Industry Standard