Tissue Models | 3D Cell Culture Models | Life Sciences | Corning

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Explore Tissue Environments with Solid Synthetic Scaffold Models

Mimic a broad range of 3D tissue microenvironments using solid synthetic scaffold models. Because synthetic scaffolds are devoid of animal-derived materials, they are free of potential pathogens and other issues found with biologic products.

Polymers are a common choice for generating solid scaffolds of diverse size, structure, and porosity. They can be fabricated using lithography, electrospinning, bioprinting and, in the case of permeable supports, microporous membranes. For studies where endogenous factors are required to more realistically mimic the cellular in vivo environment, they can be combined with extracellular matrices (ECMs) as a coating to create effective complex matrices for 3D cell culture.

Applications

Tissue Model Applications

Organotypic Tissue Models

Organotypic Tissue Models

Organotypic Tissue Models

Developed for a variety of tissues, including skin, liver, stomach, kidney, and lung, organotypic models display a realistic micro-anatomy, mimic organ function, and offer insight into cell-to-cell interactions.

Developed for a variety of tissues, including skin, liver, stomach, kidney, and lung, organotypic models display a realistic micro-anatomy, mimic organ function, and offer insight into cell-to-cell interactions.

Bioprinting

Bioprinting

Bioprinting

3D bioprinting has been used for the generation of multilayered skin, bone, liver, and cartilage tissue models in research, toxicology, and drug-screening studies.

3D bioprinting has been used for the generation of multilayered skin, bone, liver, and cartilage tissue models in research, toxicology, and drug-screening studies.

Motility Models

Motility Models

Motility Models

The movement of cells from one area to another in response to a chemical signal is central to a variety of cell functions such as cell differentiation, wound repair, embryonic development, angiogenesis, and tumor metastasis.

The movement of cells from one area to another in response to a chemical signal is central to a variety of cell functions such as cell differentiation, wound repair, embryonic development, angiogenesis, and tumor metastasis.

Solutions for Tissue Models

Corning FluoroBlok™

Corning FluoroBlok™

A light-blocking membrane, Corning FluoroBlok™ eliminates the need to swab away non-migrating cells after a migration event, enabling both kinetic and endpoint migration and invasion assays.

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Hydrogels

Hydrogels

Natural hydrogels, such as Corning Matrigel® matrix, along with synthetic hydrogels, work together with Corning permeable support solutions to study physiological mechanisms across 3D applications.

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Application Support for Tissue Models

Application Support for Tissue Models

Permeable Supports Selection Guide

Choose the right combination of membrane type, pore size, format, and surface treatment to create a cell culture environment that more closely mimics the in vivo environment you desire.

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Keratinocyte Differentiation in Organotype Models

Learn how an immortalized keratinocyte cell line, Ker-CT, is able to differentiate into organotypic skin equivalents in a 3D culture model.

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Cell Migration, Chemotaxis, and Invasion

Utilizing Transwell permeable supports, this protocol outlines the steps for conducting a cell invasion assay through a BME barrier with notes for conducting a chemotaxis assay.

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Fluorescence-Based Tumor Cell Invasion Assay

Using the FluoroBlok insert system, Corning researchers tested anti-metastatic compounds to develop a fluorescence-based tumor cell invasion assay system.

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Scientific Support–Setting a New Industry Standard

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