Tissue Fractions | Advanced Optics | Corning

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Enhance the Results of Your ADME Metabolism Studies

By choosing Corning® Gentest™ tissue fractions, you will be able to conduct preclinical metabolism studies to predict the toxicity and pharmacokinetic properties of a drug compound, including metabolic stability, drug-drug interactions, reaction phenotyping, and metabolite identification. Our broad selection of liver and intestinal tissue fractions are highly characterized for important metabolizing enzymes such as CYPs, UGTs, and other enzymes. The fractions are offered as pooled or as single donors.

The pooled donors represent an average profile of catalytic activities from many individuals and are most suited for controlling the inter-individual variability in quantitative studies of metabolism. The Corning UltraPool™ HLM 150 is the first commercially available large donor pool. This product better represents the average patient population and known CYP polymorphisms, enabling consistent experimental results in multi-year programs, and offering a time savings by reducing the time required to qualify new lots of HLMs.

The single donor HLM pools offer activity levels from high to low representing the heterogeneity of expression of individual P450s found in the human population. These products provide flexibility to select from a broad range of donors at different CYP catalytic activity levels and enable to study the metabolism of specific CYPs and to phenotype and correlate CYP activities.

Many steps are taken during the manufacture of all Corning Gentest Tissue Fraction products to ensure quality and to reduce lot-to-lot variability. Corning adheres to high ethical standards and strict traceability for obtaining human materials and only sources from US-based Organ Procurement Organizations. High safety standards are also followed including serological testing prior to acceptance, followed by PCR testing for HIV I/II, Hepatitis B, Hepatitis C, and HTLV - I/II and syphilis.

Corning Gentest Tissue Fractions

How to Buy

Purchasing Options

Order Now

Order Now

It’s easy to purchase related Corning Gentest tissue fractions online. Just browse our online catalog, and add products directly to your cart. Order direct with a credit card or use a purchase order if you have an account with Corning.

It’s easy to purchase related Corning Gentest tissue fractions online. Just browse our online catalog, and add products directly to your cart. Order direct with a credit card or use a purchase order if you have an account with Corning.

Distributors

Distributors

Only select distributors in Canada sell Corning transporter model systems. For global customers outside of Canada, please contact your regional Corning office.

Only select distributors in Canada sell Corning transporter model systems. For global customers outside of Canada, please contact your regional Corning office.

Customer Service

Customer Service

If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.

If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.

What’s New

Featured Products, Resources, and More

Optimizing Donor Number for Consistent Pooled HLMs

Optimizing Donor Number for Consistent Pooled HLMs

An overview analysis of the CYP activity distributions for over 300 donors.

Optimizing Donor Number for Consistent Pooled Human Liver Microsomes

Based on a detailed statistical analysis of the variability in individual CYP activity levels for over 300 donors, the authors of this study conclude that the number of donors in pooled HLMs should be increased more than two-fold. A donor number of 150 appears to be a sweet spot providing low CVs for the major CYPs such that the variability in the HLM product is well below the overall assay variability. This conclusion has led to the decision to develop and commercialize Corning UltraPool HLM 150, a pooled HLM product comprised of 75 male donor livers and 75 female donor livers.

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UltraPool HLM 150 Characterization

UltraPool HLM 150 Characterization

Get detailed characterization data on Corning UltraPool HLM 150.

Corning UltraPool HLM 150 Characterization

This technical document provides detailed charts and graphics demonstrating the characterization of Corning UltraPool HLM 150, the first commercially available large donor pool.

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Differential Time- and NADPH-dependent Inhibition

Differential Time- and NADPH-dependent Inhibition

Learnings and conclusions from a reversible inhibition protocol.

Differential Time- and NADPH-dependent Inhibition of CYP2C19 by Enantiomers of Fluoxetine

This application note highlights a study in which its authors compared fluoxetine, its (R)- and (S)-enantiomers, ticlopidine, and the reversible CYP2C19 inhibitor S-benzylnirvanol. In a reversible inhibition protocol (30 minute preincubation with liver microsomes without NADPH), they found (R)-, (S)-, and racemic fluoxetine to be moderate inhibitors with IC50 values of 17, 67, and 27 μM, respectively, among several other important conclusions.

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Time-Dependent Cytochrome P450 Inhibition Assays

Time-Dependent Cytochrome P450 Inhibition Assays

Learn about time-dependent assay developed with adherence to applicable FDA guidance and accordance to GLP.

Validation of GLP Time-Dependent Cytochrome P450 Inhibition Assays with LC/MS Detection

This application note discusses the importance of time-dependent P450 inhibition in drug development and described a method developed by Corning Scientists.  Details on assay conditions as well as best practices for running such assays are also included.

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Support

Resources and Support

FAQs: Tissue Fractions

FAQs: Tissue Fractions

Get the answers you need to take full advantage of our full line of Corning Gentest tissue.

Frequently Asked Questions: Corning Gentest Tissue Fractions

From storage methods and stability questions to the best method to mix microsomal suspensions, get answers to commonly asked questions about using Corning Gentest tissue fractions to support all of your metabolism-based assays.

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ADME Technical Resources

ADME Technical Resources

We provide a range of technical materials (e.g., application notes, bulletins, instruction manuals, and selection and use guides) that support our products and key applications.

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Corning Gentest Contract Research Services

Corning Gentest Contract Research Services

Get assistance from expert ADME Study Directors.

Take your research to the next level with expert assistance from our Contract Research Services

Need specialized research support? Our ADME Study Directors stand ready to become an extension of your teamor your virtual partnerto help strengthen your ability to meet your drug discovery and pre-clinical goals. Corning Gentest Study Directors are knowledgeable in ADME research and regulatory compliance and stay current with rapidly changing technological and regulatory developments.

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