Tissue Fractions | ADME Metabolism and Liver Microsome Products | Corning

We use cookies to ensure the best experience on our website.
View Cookie Policy
_self
Accept Cookie Policy
Change My Settings
ESSENTIAL COOKIES
Required for the site to function.
PREFERENCE AND ANALYTICS COOKIES
Augment your site experience.
SOCIAL AND MARKETING COOKIES
Lets Corning work with partners to enable social features and marketing messages.
ALWAYS ON
ON
OFF

Enhance the Results of Your ADME Metabolism Studies

Enhance the Results of Your ADME Metabolism Studies

By choosing Corning® Gentest™ tissue fractions, you will be able to conduct preclinical metabolism studies to predict the toxicity and pharmacokinetic properties of a drug compound, including metabolic stability, drug-drug interactions, reaction phenotyping, and metabolite identification. Our broad selection of liver and intestinal tissue fractions are highly characterized for important metabolizing enzymes such as CYPs, UGTs, and other enzymes. The fractions are offered as pooled or as single donors.

The pooled donors represent an average profile of catalytic activities from many individuals and are most suited for controlling the inter-individual variability in quantitative studies of metabolism. The Corning UltraPool™ HLM 150 is the first commercially available large donor pool. This product better represents the average patient population and known CYP polymorphisms, enabling consistent experimental results in multi-year programs, and offering a time savings by reducing the time required to qualify new lots of HLMs.

The single donor HLM pools offer activity levels from high to low representing the heterogeneity of expression of individual P450s found in the human population. These products provide flexibility to select from a broad range of donors at different CYP catalytic activity levels and enable to study the metabolism of specific CYPs and to phenotype and correlate CYP activities.

Many steps are taken during the manufacture of all Corning Gentest Tissue Fraction products to ensure quality and to reduce lot-to-lot variability. Corning adheres to high ethical standards and strict traceability for obtaining human materials and only sources from US-based Organ Procurement Organizations. High safety standards are also followed including serological testing prior to acceptance, followed by PCR testing for HIV I/II, Hepatitis B, Hepatitis C, and HTLV - I/II and syphilis.

Corning Gentest Tissue Fractions

How to Buy

Purchasing Options

Order Now

Order Now

It’s easy to purchase related Corning Gentest tissue fractions online. Just browse our online catalog, and add products directly to your cart. Order direct with a credit card or use a purchase order if you have an account with Corning.

It’s easy to purchase related Corning Gentest tissue fractions online. Just browse our online catalog, and add products directly to your cart. Order direct with a credit card or use a purchase order if you have an account with Corning.

Scientific Support

Scientific Support

Our experienced team of scientists and support specialists is ready to assist you with application questions, troubleshooting advice, and product selection.

Our experienced team of scientists and support specialists is ready to assist you with application questions, troubleshooting advice, and product selection.

Customer Service

Customer Service

If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.

If you need assistance selecting products, or if you’d like to order by phone, fax, or email, please contact us.

Related Products

You may also be interested in these products.

Compartir