Recombinant Metabolic Enzymes

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Robust Activity, High Quality, First Choice by Researchers

The Corning® Gentest™ Supersomes™ recombinant drug metabolizing enzymes product line includes more than 40 different human and animal cytochrome P450 isoforms, UDP-glucuronsyl transferases (UGTs), Flavin-Containing Monooxygenases (FMOs), monoamine oxidases (MAOs), soluble N-Acetyltransferases (NATs), and carboxylesterases (CESs).

These products are manufactured using baculovirus-transfected insect cells and exhibit very high levels of catalytic activities. Side-by-side comparisons of the catalytic activity with pooled human liver microsomes (HLMs) are available for many enzymes.

The data are available by email: Scientificsupport@corning.com

By choosing these superior quality reagents, you will have the tools you need for screening drug interactions, studying slowly metabolized chemicals, or manufacturing large-scale production of metabolites for structural identification.

Recombinant Supersome Enzymes

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Corning Supersomes Enzymes Application Note

Corning Supersomes Enzymes Application Note

Review different approaches to assessing the contribution of individual CYP isoforms to a drug’s clearance at the stage of drug discovery.

Cytochrome P450 Enzyme Mapping in Drug Discovery using Corning Supersomes Enzymes

See how the approach of relative quantitation by assessing substrate depletion is a desirable and beneficial way to screen for properties and pathways in drug discover and lead optimization. Learn how to apply RAF method and ISEF method in data analysis.

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FAQ for Cytochrome P450 Inhibition Assays

FAQ for Cytochrome P450 Inhibition Assays

Check out this technical note to learn how to set up enzyme inhibition assays using supersome enzymes, HLM and hepatocytes

Corning® Gentest™ Cytochrome P450 Inhibition FAQ

Understand why and how are these assays are performed. Learn the tips and best practices for setting up these experiments.

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Need to outsource your ADME/Tox studies?

Need to outsource your ADME/Tox studies?

Get expert assistance from Corning Gentest Contract Service Team.

Corning Gentest Contract Research Services

Need specialized research support? Our ADME Study Directors stand ready to become an extension of your team—or your virtual partner—to help strengthen your ability to meet your drug discovery and pre-clinical goals. Corning Study Directors are knowledgeable and stay up-to-date with rapidly changing technological and regulatory developments.

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Technical Resources

Technical Resources

Technical Resources

We provide a range of technical materials (e.g., application notes, bulletins, instruction manuals, and selection and use guides) that support our products and key applications.

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