Synthemax Vitronectin Substrate | Life Sciences | Corning.com

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Support and enhance stem cell adhesion and expansion with Corning Synthemax vitronectin substrate

Support & enhance stem cell adhesion and expansion

Create a more in vivo-like environment for stem cell culture with Corning Synthemax vitronectin substrate—an animal-free, synthetic, flexible vitronectin-based peptide substrate for serum or serum-free expansion of hPSCs and other adult stem cell types. Synthemax vitronectin substrate also offers a synthetic, xeno-free alternative to biological coatings and/or feeder cell layers used in hES and iPS cell culture.

Amendable to coating Corning microcarriers for larger-scale stem cell expansion applications, Synthemax vitronectin substrate allows for:

 

  • Scalable, multi-passage expansion of pluripotent stem cells in serum-free media, such as mTeSR™.
  • Differentiation into a number of cell types, including retinal pigment epithelial cells and cardiomyocytes.
  • Propagation of various progenitor cell types.

Synthemax Vitronectin Substrate

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Support Multipassage Culture of hiPSCs in Defined

Support Multipassage Culture of hiPSCs in Defined

Corning Synthemax vitronectin substrate is a synthetic self-coating substrate for pluripotent stem

Support multipassage culture of hiPSCs in defined medium with Synthemax vitronectin substrate.

hiPSCs cultured on Synthemax II-SC Substrate coated plates maintain pluripotency markers, normal karyotype and ability to differentiate to cells of all three germ layers 

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Long-term Self-renewal of Human Embryonic Stem

Long-term Self-renewal of Human Embryonic Stem

Take a look at this poster presenting data on Corning Synthemax vitronectin substrate for hESC

Synthemax Vitronectin Substrate: A Synthetic, Xeno-free Surface for Long-term Self-renewal of hESC

Advantages of Synthemax Vitronectin Substrate for hESC culture include:
• Support of long-term, multi-passage expansion of undifferentiated H7, H1, and BG01v hESC in several commercially available defined media.
• Retention of consistent doubling time, phenotypic market expression, karyotype, and in-vivo pluripotency of hESCs.
• Scalable culture of hESC for therapeutic applications when combined with chemically defined media.

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Synthemax Vitronectin Substrate Self-coating

Synthemax Vitronectin Substrate Self-coating

This protocols provides a guide to using self-coating Synthemax vitronectin substrate for stem cell

Synthemax Vitronectin Substrate Self-coating Protocol

From materials to correct procedures, this protocol outlines how to use Synthemax vitronectin substrate for the culture of stem cells. 

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Culturing hESCs on Corning Synthemax Vitronectin

Culturing hESCs on Corning Synthemax Vitronectin

This protocol provides a guide to using self-coating Synthemax vitronectin substrate for culturing

Culturing hESCs on Corning Synthemax Vitronectin Substrate

Current methods to maintain hESCs in an undifferentiated state often employ mouse feeder layers or biological substrates, but these methods can be difficult to work with, inconsistent and can introduce the possibility of contamination from the animal source. This protocol describes maintenance of human embryonic stem cells H1 and H7 WiCell® lines on Synthemax vitronectin substrate using a chemically defined medium.

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