Webinars | Advanced-Flow Reactors | Corning

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Free webinars delivered by Corning’s flow chemistry experts

Free webinars delivered by Corning’s flow chemistry experts

We are excited to present our Advanced-Flow™ Reactor (AFR) Webinar Series that covers a range of relevant topics intended to help you realize the value of flow chemistry and Corning’s reactor technologies while also learning more about auxiliary equipment and flow chemistry applications.

The AFR Webinar Series is designed to offer something for everyone, no matter your role or experience level in flow chemistry. We look forward to connecting with you soon.

Browse live and recorded webinars and register via the links below, or contact us at AFRwebinar@corning.com for more information.

Live Webinars

  • June 2021
    • Efficiency in API manufacturing through continuous flow

      Presenters: 
      Dr. Dirk Hütten, Raybow Pharmaceutical
      Alessandra Vizza, Corning Reactor Technologies

      This webinar will focus on reaction design and scale-up for larger production. Attendees will explore the benefits of continuous flow reactions in pharmaceutical API & Intermediate manufacturing. Raybow Pharmaceutical has a long history in the field with experience in R&D as well as manufacturing with multiple continuous flow reactors, the largest one of which produces more than 140 tons API per year.

      Session #1
      Tuesday, June 1
      10:00am Central European Time
      13:30pm Indian Standard Time
      Register >

      Session #2
      Thursday, June 3
      11am Eastern Daylight Time
      20:30pm Indian Standard Time
      Register >

Recorded Webinars, Q&A Documents

  • #1: Stepping into Corning® Advanced-Flow™ Reactor Technology: An Industrial Overview

    Access Recording >
    Webinar #1 Q&A >

    Presenter: Dr. Guillaume Gauron

    What is flow chemistry? What are the advantages of running processes in a continuous way? How does Corning technology apply to it? This webinar focuses on several cases of flow chemistry applications that have been seamlessly transferred from lab scale directly to industrial production.

    • Abstract

      Chemistry has been traditionally performed using batch processing techniques, but what is flow chemistry and what advantages could it bring to your processes? Over the last 18 years, Corning has brought to the chemical process industry a powerful process intensification platform: Corning® Advanced-Flow™ Reactors (AFR) and their application technologies, which cover lab-scale flow process development to seamless scale-up of flow processes for commercial production.

      This webinar provides a short introduction to Corning AFR Technology and describes the advantages of using flow chemistry compared to more conventional batch chemistry. A description of AFR Technology highlights key aspects such as 100x higher mixing, 1000x better heat transfer and the unique seamless scale-up feature. But the main focus of the webinar is on several cases of applications that have been seamlessly transferred from lab scale directly to industrial production.

      The six examples shared during the presentation provide a broad overview of the different reasons to switch to flow chemistry. From the high control required for nanoparticles synthesis, the use of forbidden chemistries such as azide, nitration or oxidation, as well as the need to upgrade old chemistries to increase quality and decrease cost or reduce footprint. The real cases shared by our customers around the world provide great insight into the use of flow chemistry from lab to more than 10,000 metric tons/year production.

  • #2: How to Analyse your Batch Process Data to Transition from Batch to Flow

    Access Recording >
    Webinar #2 Q&A >

    Presenter: Dr. Philippe Roth

    Processes can be “translated” from traditional batch recipes to flow, or developed from scratch in flow. This course aims to help you apply the knowledge you have acquired in batch chemistry to get insight into flow chemistry. We’ll see how to analyse batch processing data in order to successfully transition from batch to flow and how to avoid common mistakes.

    • Abstract

      Synthesis in Chemistry formal lectures and teaching labs tend to be taught using an historic batch process approach. As many chemists are not taught using a flow chemistry approach, most of this knowledge is acquired in batch process. However,  flow chemistry brings powerful options, and this course aims to help you apply the knowledge you have acquired in Batch Chemistry to get insight into flow chemistry.

      The presentation describes the classification of chemical reactions based on kinetics and how flow chemistry is suitable for this. Then common mistakes are described (happening either before , during or after the reaction) to help researchers perform their research and avoid common (and often overlooked) issues. The course also includes guidelines to help you know how to switch a process and which steps to follow.

      This presentation also provides tips on how to look through research papers to extract data from batch to flow chemistry. This will help research scientists to grasp which piece of information is useful, which one is overlooked and how to make the most of it. This includes reading through reported reaction time for instance.

      Lastly, a real case example of a diazo reaction is described, highlighting the process to get there and how to adapt it. This whole approach can be better grasped by research scientists and used in their own project.

  • #3: Making the Switch to Flow Chemistry: How to decide if implementing flow chemistry is feasible for your process.

    Access Recording >
    Webinar #3 Q&A >

    Presenter: Mr. Marc Winter

    What are the ideal conditions and hurdles to move to flow chemistry? The benefits of microreactors and flow chemistry have been demonstrated across the chemical manufacturing industry for a variety of processes, but not every process is a good candidate.

    Watch this webinar to identify the potential benefits of switching to flow chemistry and gather general advice and hints that will help you decide if flow chemistry would be a good fit for your process.

  • #4: How to Leverage Corning® Advanced-Flow™ Reactor Technology for Photochemistry Applications

    Access Recording >
    Webinar #4 Q&A >

    Presenter: Dr. Philippe Roth

    Due to its interaction with matter, ultraviolet (UV) light can trigger specific reactions and open new routes. Photochemistry is a powerful tool but is often underused by scientists. However, with the improvement of global photochemistry technologies and increased adoption of flow chemistry, new options have emerged. This course highlights the key parameters to look at while performing photochemistry using Advanced-Flow Reactor Technology.

  • #5: Necessary Equipment to Run a Continuous Flow Reactor: Upstream equipment

    Access Recording >
    Webinar #5 Q&A >

    Presenter: Dr. Ancuta Musina

    Corning® Advanced-Flow™ Reactors have been designed to maximize mixing and heat transfer. Consistent and pulseless flow is a key parameter for flow chemistry as any fluctuation in the flow of the chemical can cause the final product to drift out of tolerance. Therefore the selection of appropriate dosing pumps is paramount for a successful continuous-flow process. In the same time, to benefit of the reactor's heat transfer efficiency, the choice of the heat exchange unit is very important. Watch this webinar to learn how to pair material dosing lines (e.g., pumps, flow meters) and temperature controllers (e.g., chillers, heat exchangers) with your continuous flow reactor.

  • #6: Corning AFR Qualified Lab work – Citos - Reactions with molecular oxygen: from the preparation of active pharmaceuticals to the neutralization of chemical warfare agents

    Access Recording >

    Presenter: Dr. Jean-Christophe Monbaliu

    This webinar illustrates the rationale behind the development of continuous flow processes relying on molecular oxygen. The use of oxygen for large scale preparative applications is often seen as challenging in organic chemistry both for safety and practical issues. The direct use of molecular oxygen will be illustrated for the preparation of value-added intermediates for pharmaceutical production or other high-end applications. The generation and use of much more reactive oxygenated species, such as singlet oxygen, will be documented as well for preparative chemistry and for the oxidative destruction of chemical warfare agents. Such applications rely on the synergistic combination of light, an organic photosensitizer and ground state molecular oxygen. 

  • #7: Stepping into Corning® Advanced-Flow™ Reactors: Application in Material Sciences via Nanoparticles Synthesis

    Access Recording >
    Webinar #7 Q&A >

    Presenter: Dr. Philippe Roth

    Emerging as a mega-trend and shaping the world in a new way, nanoparticles are everywhere. The ability to synthesize them remains challenging and requires extreme precision. As flow chemistry is a powerful tool for synthesis, it can offer a different way of thinking and synthesizing nanoparticles. This talk shows through different examples the impact flow chemistry can have on the field.

  • #8: Optimization and Seamless Scale-up in Corning® Advanced-Flow™ Reactors

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    Presenter: Mr. Marc Winter

    Corning AFR Technology has been designed to help the chemical and pharma industries optimize their processes and speed up their time to market. The great R&D work performed by Corning experts leads to a flow chemistry technology which is not only scalable but enables seamless scale-up.

    This webinar presents some of the innovation developed and how this enables customers from around the world to move to production inherently safer and quicker while keeping high quality standards. Through examples and case studies we discuss how achieving production scale is possible as well as process design optimization.

  • #9: Considerations in Scaling Photochemistry – Case Studies from the CC FLOW Labs

    Access Recording >

    Presenter: Dr. Jason Williams

    Photochemistry holds significant promise in organic synthesis, with the dissemination of a large number of new methodologies. As a result, there will be increasing pressure on process development chemists in coming years, to scale up photochemistry-containing routes developed on smaller scale. Continuous flow processing has a key role to play as an enabling technology, but comes with additional complexities. This webinar shows case studies from the CC FLOW labs, discussing the scale-up considerations for a range of photochemical processes.

  • #10: Corning® Advanced-Flow™ Reactors Portfolio and Services – focused on customer-driven innovation

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    Presenter: Dr. Guillaume Gauron

    Corning has a long track-record of innovation spanning our 170-year history, with materials science at our core. For more than 17 years, Corning has developed and evolved its AFR technology to help meet customer requirements. From the lab to multi-ton production scale, to reactors and auxiliaries; from academic collaboration to customer training and technical support, Corning AFR is committed to delivering high quality products and unparalleled support to our customers. This webinar gives more insight into our portfolio of equipment and related services.

  • #11: Corning AFR Qualified Lab work – Citos: Handling toxic and unstable intermediates. The optimum chemistry with the right technology.

    Access Recording >

    Presenters:
    Dr. Andrea Adamo, Zaiput Flow Technologies
    Trevor Murray, Zaiput Flow Technologies
    Dr. Jean-Christophe Monbaliu, University of Liège
    Dr. Guillaume Gauron, Corning Reactor Technologies

    Flow chemistry provides a rather broad set of advantages that range from process robustness, ease of scale up, to access otherwise very challenging reaction conditions. Harvesting the full benefits of flow chemistry requires in-line work-up capabilities integrated within the flow process. In this talk, we highlight how in-line continuous and scalable liquid-liquid extraction provided by the Zaiput’s line of separators aids in a full continuous process integration which provides safe operation in a compact foot print. Specifically, the minimal internal volume, lack of head space and inherently safe continuous operation of the separators, provide a valuable tool to process hazardous materials. Further, the  scalability of the technology provides a straightforward path to the production of larger quantities of material. Among different examples, we will highlight a recently published case where flow reactions and workups are utilized to manage the reactivity and toxicity of α-chloronitroso derivatives in various conditions.

  • #12: Continuous Manufacturing of Nanostructured Materials in a Corning® Advanced-Flow™ Reactor

    Access Recording >

    Guest Presenter: Dr. Kejun Wu, Zhejiang University 

    A lot of promising nanostructured materials (NM) technologies never reach the market due to issues with the scaling-up process required to produce large quantities. Microreactor-based processes offer considerable advantages, including excellent control of mixing, heat and mass transfer, reproducibility, and seamless transition from lab-scale to large production. This webinar showcases studies from Dr. Wu's group, discussing the hydrodynamics and mixing behaviour and Ag NM continuous production in Corning Advanced-Flow Reactors.

Presenters

Presenters

Dr. Andrea Adamo

CEO and founder, Zaiput Flow Technologies

Dr. Andrea Adamo, CEO and founder of Zaiput Flow Technologies, is an engineer and entrepreneur with extensive experience in the development of innovative solutions in the context of fluid flows. Dr. Adamo holds a Master of Science in Engineering from the University of Palermo, Italy and a Ph.D. in Fluid Mechanics from the University Federico II of Naples, Italy in addition to a Master of Science from the Massachusetts Institute of Technology. He was also awarded the Fulbright Scholarship. After completing his graduate studies, Dr. Adamo joined the laboratory of Prof. Klavs Jensen, first as Postdoctoral Associate and then as a Research Associate. In the Jensen group he worked on different applications of microfluidics, microchemistry and flow chemistry. He had a key design role in the context of the Pharmacy on Demand and Molecules on Demand projects sponsored by the Defense Advanced Research Projects Agency (DARPA). Dr. Adamo developed the technology at the core of Zaiput, he currently serves as the Innovation Advisor at Snapdragon Chemistry.

Dr. Guillaume Gauron

EMEA Technical Sales Manager, Corning Reactor Technologies

After earning his Ph.D. in Organic Chemistry from Orsay University Paris XI in 2007, Guillaume worked as an R&D chemist at Cis Bio from 2008 to 2014 before joining Corning Reactor Technologies as an application engineer. In 2018, Guillaume accepted the role of EMEA Technical Sales Manager.

Dr. Dirk Hütten

Senior Director Business Development, Raybow Pharmaceutical

Dr. Dirk Hütten holds a PhD in Chemistry from the University of Cologne, Germany. He has more than 20 years of experience in global sales and marketing alongside the supply chain of pharmaceuticals and APIs including positions at GSK, Altana and PharmaZell. In 2019, he joinedRaybow Pharmaceutical as Senior Director Business Development. In addition, Dirk is passionate about high performance sailing.

Dr. Jean-Christophe M. Monbaliu

Associate Professor, University of Liège

Dr. Jean-Christophe M. Monbaliu is currently Associate Professor at the University of Liège (Belgium) and serves as Associate Editor of the Journal of Flow Chemistry. He is heading the Center for Integrated Technology and Organic Synthesis (CiTOS, www.citos.uliege.be), the first European Corning® Advanced-Flow™ Reactor qualified lab. His research interests revolve around synthetic organic chemistry but are multidisciplinary in essence. They aim at (a) designing cheaper and more efficient routes for the preparation of high value-added chemicals such as active pharmaceutical ingredients, (b) accelerating the transition from petrobased to biobased strategies and (c) developing efficient processes with a lower environmental impact.

Trevor Murray

Sales Engineering Director, Zaiput Flow Technologies

Trevor Murray is the Sales Engineering Director at Zaiput Flow Technologies, an MIT spinout, that is leading innovation in flow chemistry and continuous processing – two up and coming trends in the pharmaceutical industry. Trevor joined Zaiput as an application engineer in 2018 and has since led Zaiput’s sales and business development efforts. He works with scientists and engineers from many of the top pharmaceutical companies around the world to help them implement continuous separation technology to enable new chemistries and improve their current processes. Trevor graduated from Northeastern University in 2018 with a Bachelors Degree in Chemical Engineering. While a student, Trevor held positions at multiple biotech companies, focusing on novel drug delivery, process design and optimization.

Dr. Ancuta Musina

Application Engineer, Corning Reactor Technologies

After graduating with her masters in Chemical Engineering from the University Politehnica of Bucharest in 2012, Anca worked as an R&D Engineer in the development of new processes using chelating resins. In 2014, she started her PhD in parallel and graduated in 2019. In 2018, Anca joined Corning as an Application Engineer for the Corning® Advanced-Flow™ Reactors business.

    

Dr. Philippe Roth

Application Engineer, Corning Reactor Technologies

After graduating with a Ph.D. in Organic Chemistry from Oxford University in 2014, Philippe worked as an R&D scientist in agrochemistry and then as an analytic chemist in pharmaceutical companies before joining Corning® Advanced-Flow™ Reactors as an Application Engineer in 2018.

Alessandra Vizza

Regional Business Director, Corning Reactor Technologies

Alessandra Vizza is the Regional Business Director for the Advanced-Flow™ Reactors business at Corning. She has been with the company for the last ten years, working first as Application Engineer ensuring technical contact with customers, being in charge of installations and applications.

She later took over a Commercial Manager role for EMEA and NSA regions. Then, she moved to her current role ensuring the business continuity for Advanced-Flow™ Reactors. She has experience in the technical application of Corning's Advanced-Flow™ Reactors as well on market strategy and business development.

Over the course of her career in flow technology, Alessandra has been co-author of several articles and provided several talks and workshops and also built collaborations with several Academic and Service companies. She is focusing her activity on the successful implementation of industrial cases.

Prior to Corning, Alessandra Vizza was working in the field of food plants as R&D engineer. She earned a masters degree in Food & Technology from Università Statale di Milano.

Dr. Jason Williams

Principal Scientist, Research Center Pharmaceutical Engineering

Jason Williams is a Postdoctoral Researcher at the Center for Continuous Flow Synthesis and Processing (CC FLOW), based in Graz (Austria). He completed an undergraduate degree in Chemistry (2014) at the University of Sheffield (UK), with a year industrial experience in medicinal chemistry at AstraZeneca. This was followed by a PhD on the GlaxoSmithKline/University of Strathclyde collaborative PhD Programme, under the supervision of Prof. Billy Kerr, working on novel amidation methods enabled by new synthetic technologies such as flow and photochemistry. Since 2018, Jason has worked in the Kappe group as part of CC FLOW, where his research interests are based in the area of flow photochemistry as well as PAT and process control in flow.

Mr. Marc Winter

Senior Application Engineer, Corning Reactor Technologies

Marc Winter is an expert in the industrialization of flow processes. He works as Senior Application Engineer in Corning's Advanced-Flow™ Reactor business since 2007 and leads the Application Engineering Team. He has already conducted many successful projects helping international customers to move to continuous production. Among the most notable ones, he supported a customer in setting up a large scale nitration under cGMP conditions for a pharmaceutical production. Additionally to his every day task in assisting customers, he is coauthor of scientific articles, has submitted patents in the field of micro-reactors and flow chemistry and has presented results on scientific conferences. Before joining Corning he gathered international experience by working in small and large sized companies in industries like energy, food, automotive and pharma. Marc Winter holds an engineering degree in chemical and process engineering from the University of Applied Sciences Aachen (Germany).

Dr. Kejun Wu

Professor, Zhejiang University

Dr. Kejun Wu obtained his Bachelor degree in 2007 and PhD degree in 2012 from Zhejiang University, China, both in Chemical Engineering. He joined Zhejiang University as a ZJU100 Young Professor in 2021. Previously he worked as a Lecturer in Chemical Engineering at University of Leeds, UK. His current research interests are primarily directed at the application of microreaction technology for the synthesis and manipulation of nanomaterials.

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