Product innovation is based on application. Corning has been promoting its Advanced-Flow Reactor technology for many years and is committed to helping customers realize the value and benefits of continuous manufacturing.
In 2018, the Corning AFR team worked closely with Shandong Yifeng Biochemical Co., Ltd. to build a fully automatic AFR nitrification production system with total annual flow throughput of 10,000 metric tons. Compared with a traditional plant, the average output per space was increased 10 times with overall footprint reduction of 90% and operating cost reduction of more than 20%.
In 2019, in Zhejiang Weihua New Material Science and Technology Co., Ltd., (Weihua) Corning's new G5 reactor with annual flow throughput of 10,000 metric tons per reactor was used in diazotization and hydrolysis reaction processes. Through its use of Corning’s G5 reactor, not only was the whole process fully automatic and continuous, but the yield was greatly improved, which enabled shorter reaction time, less waste, labor and space occupation, etc.
In the past year, the Corning AFR team has helped companies carry out inherently safer technical transformation of hazardous chemicals production in many provinces, especially in nitrification production plants with potential safety hazards that require urgent transformation. These successful cases of industrial application, on one hand, enable customers to apply new technologies to realize more environmentally conscious processes, more automatic and inherently safer production, and meanwhile bring considerable economic and social benefits to customers in real production. On the other hand, the production of some hazardous chemicals restricted by safety and environmental protection has been licensed due to the use of Corning’s inherently safer technology, ensuring the integrity of the chemical supply chain.
Recently the pharmaceutical industry has been faced with many challenges, including development speed, production cost, product quality, supply reliability, etc. At this stage, the outbreak of COVID-19 has been accelerating the development of new drugs, and drug production needs to be more rapid and flexible. As a result, Corning and its customers have obtained the support of the U.S. Food and Drug Administration (FDA) for the innovative application and development of continuous manufacturing technologies in the pharmaceutical industry. Corning’s unique modular, multi-functional, continuous flow synthesis production platform can meet the FDA’s rigorous compliance standards. Additionally, Corning’s reactor technologies and all system components meet high standards for safety, environmental and economic requirements. In 2017, Corning and Zhejiang Pharmaceutical Group jointly built a full continuous flow production installation with an annual flow throughput of 10,000 metric tons of vitamin intermediates. The consistent continuous production successfully achieved stable operation for more than three years. The device not only has stable product quality, but also improves the yield by more than several percentage points, while also greatly reducing the waste liquid, realizing inherently safer and clean production, with remarkable economic and social benefits for the customer.
Continuous flow technology is becoming a strategic investment field of the world pharmaceutical group and CDMO. Large international pharmaceutical groups such as Pfizer, Eli Lilly, GlaxoSmithKline and Amgen have applied continuous flow technology to the research and development, as well as the production of drugs. In large pharmaceutical and CDMO, such as Zhejiang Pharmaceutical, Tianjin Pharmaceutical, Qilu pharmaceutical, Wuxi AppTec, Zhejiang Jiuzhou pharmaceutical, Asymchem and other large pharmaceutical and CDMO, continuous flow reactor technology has become the crucial method for research and development and production platforms.
Corning’s innovative technology is not only used in the fine chemical and pharmaceutical industries, but also expanding use in the fields of agrochems, flavors and fragrances, high-performance materials, biotechnology, and high-end life nutrition products. Corning is committed to the application of new fields, so that customers can enjoy the benefits of continuous flow technology, including inherently safer production, continuity, high efficiency, stable quality and cost reduction.