The perfusion cell culture process mimics the natural flow of fluid of in vivo conditions: Fresh media goes in; spent media and byproducts come out. Unlike static modalities, such as roller bottles and stacked vessels, perfusion cell cultures help researchers achieve adherent cultures at scale with minimal space and variability — and, ultimately, less labor.
These advantages help researchers meet the increasing bioprocessing demand from the cell and gene therapy space, especially as labs search for cost-effective opportunities to scale research between preclinical trials and late-stage trials.
But how do you know when to make the switch to a perfusion setup like the Corning® CellCube® System? We asked Ann Rossi Bilodeau, Ph.D., a Senior Bioprocess Applications Scientist at Corning, and Jacqueline Dokko, an Assistant Bioprocess Product Line Manager, what scientists need to know.