Critical in drug screening and other applications such as cell therapy research, spheroids are coveted for their ability to more closely resemble the original tumor from which they were derived. The Corning Elplasia 12K open well plate was designed similarly to the Corning Elplasia 12K flask with a gas-permeable polystyrene film-bottom containing 152 microcavities per cm2 for the straightforward bulk generation of uniform spheroids in one culture condition.
The microplate footprint and removable lid make the Elplasia 12K plate ideal for sampling and imaging of spheroids. Gravity, in conjunction with the Corning Ultra-Low Attachment (ULA) surface and rounded microcavity geometry, enable the formation of approximately 12,000 spheroids of similar shape and size. Media exchange ports allows for minimal spheroid disruption during liquid handling steps. The microcavity geometry allows spheroids to remain in place throughout culture without compromising accessibility/spheroid recovery at collection time.
The Elplasia 12K plate is compatible with many tumor, normal, and primary cell types often used for 3D cell culture, and may be used across many applications including:
- Compound screening
- Personalized medicine
- Biobanking
- Cell scale-up
