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Explore Liver Organoids

Organoids generated from the liver have hepatic differentiation potential and can be a source for toxicology testing and serve as a model for liver diseases.  Lgr5+ cells can also be clonally expanded as organoids and differentiated into functional hepatocytes both in vitro and upon transplantation in vivo. Liver organoids cultured from human and animal patients can be genetically modified ex vivo before transplantation or drug screening.

Publications

Supporting Publications for Liver Organoids

Supporting Publications for Liver Organoids

In Vitro Expansion of Single Lgr5+ Liver Stem Cells

This study demonstrates that previous observations concerning Lgr5+ stem cells in actively self-renewing tissues can also be extended to damage-induced stem cells in a tissue with a low rate of spontaneous proliferation.

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Pancreas 3D Organoids and Their Genetic Manipulation

See how researchers developed culture conditions for adult stem cells that allow the long-term expansion of adult primary tissues from small intestine, stomach, liver and pancreas into self-assembling 3D organoids.

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Hippo Pathway Activity Influences Liver Cell Fate

Researchers demonstrate that Hippo pathway activity is essential for the maintenance of the differentiated hepatocyte state.

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