Gastrointestinal Organoids | Organoids | 3D Cell Culture | Corning

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Explore Gastrointestinal Organoids

The gastrointestinal (GI) tract contains adult stem cells (Lgr+) residing at the bottom of the intestinal crypt and gastric glands. Proliferation of these cells is dependent on signaling pathways governed by cell-matrix interactions. GI organoids are an important tool to study developmental process as well as for personalized medicine.

Publications

Supporting Publications for GI Organoids

Supporting Publications for GI Organoids

Supporting Publications for GI Organoids

A landmark paper from lab of Dr Hans Clevers demonstrated the development of GI organoids from single Lgr5+ cells.

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CFTR Assay in Cystic Fibrosis

Researchers established conditions allowing for long-term expansion of epithelial organoids from intestine, recapitulating essential features of the in vivo tissue architecture, to study primary intestinal organoids of people suffering from cystic fibrosis.

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Long-term Expansion of Epithelial Organoids

Discover data on technology that can be used to study inflammatory, infected, or neoplastic tissues from the human gastrointestinal tract.

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Modeling Colorectal Cancer

Using CRIPSR-Cas9-mediated engineering of human intestinal organoids, researchers successfully model colorectal cancer. 

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HPSCs and Intestinal Tissue

Using a culture system as a model to study human intestinal development, researchers were able to develop human enteroendocrine cells in vitro.

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Organoids and Colorectal Cancer Research

Organoid technology may assist in cancer genetic research and patient trials.

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