ADME/Tox Reagents and Services

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A History of Advancing Drug Discovery Research

A History of Advancing Drug Discovery Research

Founded in 1983, the Gentest brand initially focused on the use of cultured human cells in GLP genotoxicity assays. In 1985, the company expanded research activities into the area of xenobiotic metabolism by developing cytochrome P450 cDNA-expression approaches. This led to the first commercial offering of cDNA-expressed human cytochrome P450 enzymes in 1990. Since that time, the range of Gentest offerings has increased dramatically, from recombinant systems to in vivo-like systems like primary hepatocytes. Now, as part of Corning Life Sciences, the Gentest offerings continue to grow, helping you stay on the leading edge of drug discovery and development.

Our scientists are internationally recognized as leaders and innovators in cytochrome P450 cDNA-expression, in vitro xenobiotic metabolism, and drug transporter techniques. Our demonstrated commitment to research has been rewarded by the receipt of several competitive NIH grants. The results and applications of our research are reported in peer reviewed journals and at international symposia by our scientists, colleagues, and customers interested in xenobiotic metabolism.

ADME/Tox Reagents


Advancing Real-world Studies

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Corning® HepatoCells

Corning® HepatoCells

Robust. Consistent. Convenient.

Corning HepatoCells are single-use, cryopreserved cells that are an excellent alternative model to primary human hepatocytes.

Corning HepatoCells deliver:

  • Robust activity induction response for major CYP enzymes
  • ≥10 fold induction for CYP3A4 and 1A2
  • Consistent performance
  • Low lot-to-lot variation
  • High cell purity (>99% hepatocyte-like cells)
  • ≥8 x 106 cells per vial
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Corning TransportoCells SLC Transporter Cells

Corning TransportoCells SLC Transporter Cells

High performance, cryopreserved mammalian cells.

Corning TransportoCells deliver robust data, while eliminating the time required to culture and maintain stable cell lines. Assays include:

  • Reaction phenotyping to determine if a specific SLC transporter is capable of transporting a test compound from the outside to the inside of a cell.
  • Kinetic assays to determine the Km and Vmax values for the uptake of a test compound.
  • Inhibition profiling to determining IC50 and Ki values for inhibitor DDI...
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Corning Recombinant Enzyme Products

Corning Recombinant Enzyme Products

Prepared from baculovirus-transfected insect cells with very high levels of catalytic activities.

Supersomes™ Enzymes are ideal for screening high throughput drug interactions, studying slowly metabolized chemicals, or manufacturing large-scale production of metabolites for structural identification.  Corning Supersomes Enzymes are prepared from baculovirus-transfected insect cells with very high levels of catalytic activities (typically 6-fold higher than an average HLM sample).

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Evaluation of Calibration Curve-based Approaches

Evaluation of Calibration Curve-based Approaches

Use Corning Gentest Human CryoHepatocytes to evaluate calibration curve-based approaches.

In a study conducted by Zhang et al, researchers were able to use Corning Gentest Human CryoHepatocytes to assess the amount of P450 induction in the liver by analyzing the concentration response curves of CYP3A4 mRNA in vitro, and established a predictive relationship between the chance in AUC in humans and parameters from CYP3A4 mRNA activity in vivo.

This research supports the use of calibration curve models and human hepatocytes to predict CYP3A4 induction potential in human patients, which can pave the way for clinical trials of potential new drug...

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TransportoCells FAQs

With the introduction of the solute carrier (SLC) over-expressing Corning TransportoCells, we have expanded our TransportoCells offering to conduct screening and use a step-wise approach for drug-drug interaction assays.

Questions? Download this FAQ on our new line of cryopreserved SLC transporter cells, or contact us.

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Webinar: A Novel “Thaw and Go” Cell-based Model to Study SLC Transporters

See how our recently introduced TransportoCells products support in vitro assessment of drug interaction with SLC transporters. This new model provides a convenient “thaw and go” cell-based model with robust activity and consistent performance.

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Keep Your Research Fresh

Register for HepatoLink™ to receive up-to-date notifications when fresh human hepatocytes are available.

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