Three-dimensional (3D) cell culture models offer significant improvements over traditional two dimensional monolayer cell culture in terms of maintaining morphological and functional characteristics of tissue. These models are increasingly being incorporated in drug discovery as ideal systems to study disease or screening for chemotherapeutic efficacy or drug toxicity.
This presentation will demonstrate:
- The use of Corning® spheroid microplates to culture and assay spheroids in a rapid and highly reproducible format
- The formation of hepatospheres using Corning HepatoCells an immortalized alternative to primary human hepatocytes, in combination with the SCREEN-WELL Hepatotoxicity library from Enzo Life Sciences for 3D hepatotoxicity screening
- The use of the Corning spheroid microplates to generate spheroids comprised of multiple cell types