The importance of genetic variations in drug transporters for drug disposition and response has been increasingly recognized in the past decade. The drug transporter organic anion transporting polypeptide 1B1 (OATP1B1) is genetically polymorphic and plays a major role in hepatic uptake of a variety of clinically important drugs. Predicting the pharmacokinetic effect of these genetic variants on the drug disposition is critical for understanding the inter-individual variations to drug efficacy and safety. Corning® TransportoCells™ were introduced to support in vitro assessment of drug interaction with SLC transporters. Specially, the newly developed TransportoCells OATP1B1 SNPs, alongside OATP1B1 wild type, offer an in vitro tool kit for studying the potential impact of genetic variants on drug PK.
This webinar will focus on the development and characterization of the newly available TransportoCells OATP1B1 genetic variants, three animal species OATP family members, and other drug transporters of emerging importance in drug development.
Dr. Na Li received her B.S degree in Biology from Fudan University, Shanghai, China, and her Ph.D. in Pharmacology from Dartmouth Medical School, Hanover, NH. Her major research focus is on drug transporters, including interspecies differences in hepatobiliary transporters, transporter quantification, and in vitro-to-in vivo extrapolation of drug pharmacokinetics. At Corning, Dr. Li contributes her expertise in in vitro drug transporter technology and its application in drug ADME.