Visit Corning at AACR 2018 to see the latest solutions for cancer research, 3D cell culture, and drug discovery in exhibit 1842. Featured solutions will include:
Tuesday, April 17 | 10:00 - 11:00 a.m.
Spotlight Theater C in the Exhibit Hall | McCormick Place Convention Center
The world of 3D cell culture is exploding with more and more researchers generating innovative 3D cancer models never before possible. In this tutorial, Dr. Tessa DesRochers from KIYATEC will discuss assays that build upon the increased biological fidelity of 3D cell culture to accurately predict individual patient-specific glioblastoma response to chemotherapy. These assays utilize primary patient tumor tissue or PDX propagated tissue. Assay results have been correlated to clinical response, biomarker expression, and PDX response. This talk will have a particular focus on the correlative evidence for, and clinical potential of, GBM/AA cancer progenitor cell-based assays.
Hilary Sherman from Corning will discuss a novel 3D glioma blood brain barrier (BBB) model for high throughput testing of tumoricidal capability. Traditionally, high throughput glioblastoma testing requires testing for cytotoxic compounds in addition to testing for a drug’s ability to pass the BBB. Here we will demonstrate how you can test glioblastoma cytotoxicity and BBB permeability in one assay by combining Corning permeable supports with Corning spheroid microplates, resulting in an easy-to-use, 3D, high throughput glioma spheroid toxicity assay.
Tuesday, April 17 | 10:00 - 11:00 a.m.
Spotlight Theater C in the Exhibit Hall | McCormick Place Convention Center
The world of 3D cell culture is exploding with more and more researchers generating innovative 3D cancer models never before possible. In this tutorial, Dr. Tessa DesRochers from KIYATEC will discuss assays that build upon the increased biological fidelity of 3D cell culture to accurately predict individual patient-specific glioblastoma response to chemotherapy. These assays utilize primary patient tumor tissue or PDX propagated tissue. Assay results have been correlated to clinical response, biomarker expression, and PDX response. This talk will have a particular focus on the correlative evidence for, and clinical potential of, GBM/AA cancer progenitor cell-based assays.
Hilary Sherman from Corning will discuss a novel 3D glioma blood brain barrier (BBB) model for high throughput testing of tumoricidal capability. Traditionally, high throughput glioblastoma testing requires testing for cytotoxic compounds in addition to testing for a drug’s ability to pass the BBB. Here we will demonstrate how you can test glioblastoma cytotoxicity and BBB permeability in one assay by combining Corning permeable supports with Corning spheroid microplates, resulting in an easy-to-use, 3D, high throughput glioma spheroid toxicity assay.
Tessa DesRochers, Ph.D.
Dr. DesRochers is the Chief Scientific Officer of KIYATEC Inc., a predictive cancer diagnostics company pioneering methods to accurately predict individual cancer patients’ response to drugs through translational application of advanced 3D cell culture technology. She has over a decade of experience combining biology and engineering to develop 3D models of human tissue, including skin, kidney and numerous solid tumor models with applications in the areas of toxicology, disease modeling, drug response, and infectious disease. Dr. DesRochers holds a doctorate from Tufts University’s Sackler School of Graduate Biomedical Sciences in cell, molecular, and developmental biology.
Hilary Sherman
Hilary Sherman is an Applications Scientist in the Corning Life Sciences lab located in Kennebunk, ME. Hilary has been with Corning since 2005 and has worked with a wide variety of cell types including mammalian, insect, primary, and stem cells in a vast array of applications. Her key roles at Corning involve creating technical documents such as protocols and applications notes, as well as providing technical support and training for both the Corning sales force and customers. Hilary received her B.S. degree in Biology from the University of New Hampshire in 2005.
Lynsey Willetts, Ph.D.
Dr. Lynsey Willetts joined Corning Life Sciences in 2005. She is the Business Director for the Corning Cell Culture portfolio, which includes core cell culture consumables and products for 3D culture such as Corning® Matrigel® matrix, Transwells®, and spheroid microplates.
Learn more about recently published work with novel 3D models using spheroids and microcavity technology.
Scientific Poster: A Novel Three Dimensional Glioma Blood Brain Barrier Model for High Throughput Testing of Tumoricidal Capability
Scientific Poster: Combination of Ultra-Low Attachment Spheroid Microplates with a Tissue Clearing Technique for Easy-to-Use 3D Cell Culturing and True 3D Characterization
Scientific Poster: 3D High Content Screening of Liver Spheroids
Scientific Poster: Bulk Production of Cell Aggregates in Microcavity Vessels and Dispensing to Corning® Microplates for High Throughput Screening
Create sophisticated in vivo-like 3D cell culture models for tumor formation, angiogenesis, invasion and migration assays to generate more predictive results.
Create sophisticated in vivo-like 3D cell culture models for tumor formation, angiogenesis, invasion and migration assays to generate more predictive results.
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Optimize assay performance and streamline high throughput screening with assay consumables and solutions for drug screening.
Optimize assay performance and streamline high throughput screening with assay consumables and solutions for drug screening.
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Ensure consistent, reproducible, standardized cryogenic freezing and sample temperature control.
Ensure consistent, reproducible, standardized cryogenic freezing and sample temperature control.
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Boost yield, reduce variability, and create a more life-like cell culture right from the start with Corning vessels, surfaces and media.
Boost yield, reduce variability, and create a more life-like cell culture right from the start with Corning vessels, surfaces and media.
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Unlocking the complexities of cancer is an ongoing challenge. Corning supports your search for new and better ways to more effectively understand and fight cancer.
Unlocking the complexities of cancer is an ongoing challenge. Corning supports your search for new and better ways to more effectively understand and fight cancer.
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When you need accurate cell counts in a flash, turn to the world’s fastest and most accurate cell counter, now available from Corning.
When you need accurate cell counts in a flash, turn to the world’s fastest and most accurate cell counter, now available from Corning.
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