Reduce toxicity and increase cell transduction in difficult-to-transduce cell types with Corning Fibronectin surface
Improve cell attachment by using cell culture surfaces coated with Corning human fibronectin (HFN) surface. HFN is produced by a wide variety of mesenchymal and epithelial cells, and is present in both the ECM and plasma. Cell adhesion to fibronectin is mediated by the central cell-binding domain of FN through RGD (Arg-Gly-Asp) amino acid sequence. The principal functions of fibronectin appear to be in cellular migration during wound healing and development, regulation of cell growth and differentiation, and haemostasis/thrombosis.
The Corning Fibronectin mimetic surface is a pre-coated, synthetic, xeno-free, animal-free, and room temperature stable surface that mimics the natural cell environment. Fibronectin surface consists of the RGD amino acid sequence from the Fibronectin cell binding domain that facilitates cell attachment. It is coated on the surface in a manner that presents a functionally active orientation to the cells. For difficult-to-transduce and fastidious cell types, look to Corning Fibronectin surface to improve cell culture success.