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Overview
Cell Culture and Bioprocess
General Labware and Equipment
Genomics and Proteomics
HTS, Assay and Label-Free Detection
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Epic® System
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Epic Literature References
Research Publications/Book References
2007
Assay Optimization and Performance Evaluation of Cell Assays with Epic® System and Bradykinin B2 Receptors in A431 Cells. Ye Fang*, Guangshan Li. Corning REDLINES. September 2007.
Label-Free High-Throughput Functional Lytic Assays. Frutos, A., O'Malley, S., Xie, Y. (February 2007). Journal of Biomolecular Sciences.
Systems Biology and Systems Pharmacology of B2-Adrenergic Receptors in Human Epidermoid Carcinoma Cells. Fang, Y., Ferrie, A., Lahiri, J. (2007). In Meyers, J. Trends in Signal Transduction Research.
Non-invasive Optical Biosensor for Assaying Endogenous G Protein-Coupled Receptors in Adherent Cells. Fang, Y., Li, G., Ferrie, A. (June 2007). Journal of Pharmacological and Toxicological Methods. 55: 314-322.
2006
Label-free cell-based assays with optical biosensors in drug discovery. Fang, Y. (December 2006) Assay and Drug Development Technologies. 4:583-595.
Phospho-specific Recognition by 14-3-3 Proteins and Antibodies Monitored by a High Throughput Label-free Optical Biosensor. Wu, M., Coblitz, B., Shikano, S., Long, S., Spieker, M., Frutos, A., Mukhopadhyay, S., Li, M. FEBS Letters (October 2006) 580:5681-9.
Resonant Waveguide Grating Biosensors for Living Cell Sensing. Fang, Y., Ferrie, A., and Fontaine, N., Mauro, J., Balakrishnan, J. (September 2006) Biophysical Journal. 91:1925-1940.
Label-free Profiling of Endogenous G Protein-coupled Receptors Using a Cell-based High Throughput Screening Technology. Fang, Y., Ferrie, A., Li, G. (August 2006). JALA. 11: 181-187.
Cellular Functions of Cholesterol Probed with Optical Biosensors. Fang, Y., Ferrie, A., Li, G. (Feb 2006). Biochimica et Biophysica Acta 1763: 254?261.
2005
Optical Biosensor Provides Insights for Brandykinin B2 Receptor Signaling in A431 Cells. Fang, Y., Li, G., Peng, J. (October 2005). FEBS Letters 579, 6365-6374.
Optical Biosensors for Monitoring Dynamic Mass Redistribution in Living Cells Mediated by Epidermal Growth Factor Receptor Activation. Fang, Y., Ferrie, A., Fontaine, N., Yuen, P. (September 2005). IEEE Biomedical Engineering, 361:1-4.
Characteristics of Dynamic Mass Redistribution of EGF Receptor Signaling in Living Cells Measured with Label-Free Optical Biosensors. Fang, Y., Ferrie, A., Fontaine, N., Yuen, P. (September 2005). Analytical Chemistry.
Self-referencing a Single Waveguide Grating Sensor in a Micronsized Deep Flow Chamber for Label-free Biomolecular Binding Assays. Yuen, P., Fontaine, N., Quesada, M., Mazumder, P., Bergman, R., Mozdy, E. (2005). Lab on a Chip, 5(9): 959-965.
Probing Cytoskeleton Modulation by Optical Biosensors. Fang, Y., Ferrie, A., Li, G. (August 2005). FEBS Letters 579: 4175-4180.
Optical Biosensors for Cell-Based G Protein-Coupled Receptor Functional Assays. Fang, Y. (2005/2006). In Khan, M., Tailoring Ligands for G Protein-Coupled Receptors.
Presentation References
2007
SBS Tutorial: Corning® Epic® System. Frutos, A. Society for Biomolecular Sciences (SBS) Conference, April 2007.
2006
Phosphorylation Profiling: High-Throughput Label-free detection of Protein-protein Interactions Using the Epic® System. Wu, M. Johns Hopkins University. SBS 2006 Conference, September 2006.
Corning® Epic® System. Frutos, A. SBS 2006 Conference, September 2006.
The Epic® System: Label-Free High-Throughput Screening in a 384-Well Format. Frutos, A. LabAutomation 2006 Conference, January 2006.
2005
High-Throughput Label-Free Detection: Corning® Epic® System. Patnaude, L., Nelson, R., Homon, C., Frutos, A., Lynn, J. Boehringer Ingelheim Pharmaceuticals Inc. 11th Annual Conference for the Society of Biomolecular Screening, September 2005.
High-Throughput Label-Free Detection. Frutos, A. August 2005. Epic Label-Free Detection System. Frutos, A. LabAutomation, February 2005.
Overview Article References
2007
Kinase Screening and Profiling: Spoilt for Choice. Comley, J. (Winter 2006/2007). Drug Discovery World.
Culturing Creativity. Warren, C. (April 2007). NYSE Magazine.
2006
A High-Throughput Label-Free Screening Platform for Biochemical and Cell-Based Assays. Verkleeren, R., Fang, Y., Frutos, A., Fang, L., Li, G. (Oct 2006). American Biotechnology Laboratory. 24(10): 16.
Physiologically Relevant HTS Technologies: Corning® Epic® System Eliminates Chemical Labels and Permits Cell-based Screening. Verkleeren, R., Fang, Y., Frutos, A., Fang, L. (Sept 2006). Genetic Engineering News.
Current Biosensor Technologies in Drug Discovery. Drug Discovery World. Cooper, M. Summer 2006.
In The Pipeline: Corning Brings Light To Drug Discovery. Cheng. Dow Jones Newswires, 2/21/06.
2005
Pending Products May Increase Corning's Play In Cell-Based Assays, High-Content Screening. Butkus, B. Cell-Based Assay News, 11/28/05, Volume: 2, number 46.
2004
Label-Free Detection: New biosensors Facilitate Broader Range of Drug Discovery Applications. Comley, J. (2005). Drug Discovery World, Winter 2004/5, 63-74.
Scientific Poster References
2007
Non-Invasive Optical Biosensors for Probing Cell Biology. Fang, Y., Ferrie, A., Li, G., Tran, E., Verrier, F. Biophysical Society Conference, March 2007.
Label-Free High-Throughput Screening of GPCRs Using a Resonant Waveguide Grating Biosensor Platform. Fang, Y., Ferrie, A., Li, G., Randle, D., Scibek, J., Tran, E. Screening Europe, February 2007.
Applications of the Corning® Epic® System for Label-Free Antibody and Antigen Detection. Frutos, A., Xu, A. Association for Laboratory Automation Conference, January 2007.
Compound Screening Using Label-Free Cell-Based Assays on the Corning® Epic® System. Fang, Y., Frutos, A., Li, G., Randle, D., Scibek, J. Association for Laboratory Automation Conference, January 2007.
LOPAC? Screen Against Trypsin Using the Corning® Epic® System. Bunch, T., Frutos, A., Xie, X. Association for Laboratory Automation Conference, January 2007.
2006
Physiologically Relevant High-Throughput Screening against GPCRs Using Resonant Waveguide Grating Biosensor Platform. Fang, Y., Li, G., Ferrie, A. Assays and Cellular Targets Conference, October 2006.
Analysis of Small Molecule/Enzyme Interactions Using the Corning® Epic® System. Xie, X., Scibek, J., Frutos, A., Fang., L., Bunch, T., Bergsdorf, C., Eberspaecher, U., Boemer, U. Schering AG and Corning Incorporated. SBS 2006 Conference, September 2006.
Early Evaluation of the Corning® Epic® System for Label-free Functional GPCR Assays. Dodgson, K., Rawlins, P., Dale, I., Coldwell, M., Hill, S. AstraZeneca. SBS 2006 Conference, September 2006.
Label-free and High Throughput Detection of Phospho-specific 14-3-3 Protein Interactions on the Epic® System. Wu, M., Coblitz, B., Shikano, S., Long, S., Spieker, M., Frutos, A., Mukhopadhyay, S., Li, M. Johns Hopkins University and Corning Incorporated. SBS 2006 Conference, September 2006.
Analysis of Small Molecule/Protein Interactions Using the Corning® Epic® System. Fang, J., Xie, X., Frutos, A., Piech, G. SBS 2006 Conference, September 2006.
Whole Cell GPCR Assays Using Corning® Epic® System. Li, G., Ferrie, A., Fang, Y. SBS 2006 Conference, September 2006.
Analysis of Small Molecule/Protein Interactions Using Corning® Epic® System. Frutos, A., et. al. SBS 2006 Conference, September 2006.
Label-free Profiling of Ligands for Endogenous GPCRs. Frutos, A., Fang, Y., Ferrie, A, Li, G. SBS 2006 Conference, September 2006.
Analysis of Small Molecule/Protein Interactions Using Corning® Epic® System. Fang, J., Xie, X., Frutos, A., Piech, G. PharmaDiscovery 2006 Conference, May 2006.
Application of a High-Throughput, Label-Free Detection Technology for Functional and Direct-Bind Protease Assays. Xie, X., O'Malley, S., Frutos, A. MipTec 2006 Conference, May 2006.
High-Content, High-Throughput Screening of Ligands for Endogenous GPCRs Using the Corning® Epic® System. Fang, Y., Li, G., Ferrie, A. MipTec 2006 Conference, May 2006.
Drug Discovery Applications in Label-Free HTS. Aklian, M., Fang, Y., Fang, J., Ferrie, A., Frutos, A., Li, G., O'Malley, S., Nelson, R., Patnaude, L., Wildey, M., Homon, C. Johnson & Johnson PRD, Boehringer Ingelheim Pharmaceuticals, Inc., and Corning Life Sciences. ELRIG Conference, April 2006.
Label-Free Profiling of Ligands for Endogenous GPCRs Using a Cell-Based High-Throughput Screening Technology. Fang, Y., Li, G., Ferrie, A. LabAutomation 2006, January 2006.
2005
Biomolecular Assays on Label-Independent HTS System. Kong, Y., Aklian, M., Patel, D., Lynch, T., Wildey, M. Johnson & Johnson Pharmaceutical Research & Development, LLC. 11th Annual Conference for theSociety of Biomolecular Screening, September 2005.
2004
Label-Free Detection in High-Throughput Format for Cytokine Binding Interaction & Functional Kinase Assays. Kong, Y., Aklian, M., Pandey, N., Lynch, T., Wildey, M., Johnson & Johnson Pharmaceutical Research & Development and Corning Life Sciences. IBC Assays & Cellular Targets Conference, October 2004.