This session is an industry-supported symposium. Although not an official part of the 19th North American ISSX/29th JSSX Meeting, this program has been reviewed and its presentation permitted by the meeting organizers.
Join our Tutorial
Tuesday, October 21 | 7:30 a.m. – 8:30 a.m.
At Corning, we continue to invent novel technologies to facilitate pharmaceutical industry to investigate drug ADME. We will be presenting a tutorial on two new products and their applications.
Corning® HepatoCells Products: Presented by Rongjun Zuo, Ph.D., Development.
Primary human hepatocytes as the “Gold Standard” for studying metabolic fate of xenobiotics bear inherent limitations such as large lot-to-lot variability, short life span, tendency to dedifferentiate in culture, and limited supply of high quality raw materials. To overcome these shortcomings, Corning developed HepatoCells products from primary human hepatocytes. Corning HepatoCells products are a renewable source of hepatocyte like cells, which retain most of the physiological properties of their parental hepatocytes, show mature hepatocyte-like morphology, and have been characterized for CYP3A4, 1A2, and 2B6 induction response to prototypical inducers. In this tutorial, we will provide an overview of the product characterization and application of using Corning HepatoCells products for prediction of clinical CYP3A4 inducers.
Corning TransportoCells™ Products: Presented by Na Li, Ph.D.
As a key determinant of drug pharmacokinetics, transporter mediated drug-drug interaction has been brought significant attention of pharmaceutical industry and regulatory authorities. Corning offers a comprehensive list of tools to support drug transporter studies. Specially, Corning TransportoCells products was recently introduced to support in vitro assessment of SLC transporter- involved drug drug interactions. This new model provides a convenient “thaw and go” cell- based model with robust activity and consistent performance. In this tutorial, we will provide an overview of the product characterization and application of in vitro to in vivo correlation using TransportoCells products. Validation data will also be presented for the newly available transporters in the product line, including PEPT1, PEPT2, NTCP, and OATP2B1.
Corning Poster Presentations
Monday, October 20 | 4:30 p.m. – 6:00 p.m.
P156 “Use of Nominal or Time-averaged Media Concentrations of Test Compounds in Plated Hepatocyte Induction Assays to Determine EC50 Values and Relative Induction Scores: Impact on Prediction of CYP3A4 Induction Potential In vivo”. Presented by George Zhang, Ph.D., Senior Staff Scientist.
P189 “Epidermal Growth Factor Preferentially Down-regulates Basal, But Not Induced CYP3A4cyp3a4 at Supra-physiological Concentrations in Plated Human Hepatocytes”. Presented by George Zhang, Ph.D., Senior Staff Scientist.
P196 “An In vitro Screening Tool for Predicting Clinical CYP3A4 Induction”. Presented by Rongjun Zuo, Ph.D., Staff Scientist, Development.
Tuesday, October 21 | 12:30 p.m. – 2:00 p.m.
P239 “Corning® HepatoCells Products Cells Closely the Behavior of Parental Cells for Predicting Hepatotoxicity”. Presented by Ronald A. Faris, Ph.D., Director of Cell Biology.
P232 “Corning HepatoCells Products: An Alternative Hepatic Model for In vitro ADME/Tox Applications”. Presented by Rongjun Zuo, Ph.D., Staff Scientist, Development.
P252 “Characterization of Corning HepatoCells Products for Drug Uptake Transport Assay”. Presented by Rongjun Zuo, Ph.D., Staff Scientist, Development.
Wednesday, October 22 | 12:30 p.m. – 2:00 p.m.
P443 “Use of a Novel Cell-based Model to Predict Hepatic Clearance of Statins: In vitro to In vivo Correlation”. Presented by Na Li, Ph.D., Staff Scientist, Development.
P454 “A Novel Cell-based SLC Transporter Model: Validation of OATP2B1 and NTCP TransportoCells Products”. Presented by Na Li, Ph.D., Staff Scientist, Development.
P498 “Development and Characterization of a Novel Cell-based Model to Study Peptide Transporters 1 and 2- Structural Insights into Substrate / Inhibitor Recognition of Peptide Transporters”. Presented by Na Li, Ph.D., Staff Scientist, Development.