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Corning® Assay Surfaces:
High Binding Polystyrene Surface
Polystyrene is easily modified to a high binding state by the use of radiation.
The radiation effectively incorporates carboxylic acid on the accessible
carbons of the "broken" benzene ring. The resulting surface is primarily
hydrophobic with intermittent carboxyl groups capable of ionic interactions
with positively charged groups on biomolecules (Figure 1). The immobilization
mechanism is passive adsorption through hydrophobic and ionic interactions.
This is considered a general purpose surface capable of binding medium (>10kDa)
and large biomolecules that possess ionic groups and/or hydrophobic regions.
Binding capacity is increased as compared to the Medium Binding surface to
approximately 400-500ng IgG/cm2 because ionic interactions require
that a smaller portion of the molecule be in contact with the surface to obtain stable immobilization.
Figure 1. High binding polystyrene has both hydrophobic and hydrophilic
characteristics.
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